Understanding Cimzia (Certolizumab Pegol)
Cimzia is a prescription biologic medication classified as a tumor necrosis factor (TNF) blocker [1.3.2, 1.6.2]. It works by reducing inflammation to manage symptoms of several autoimmune disorders in adults. These conditions include Crohn's disease, rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), non-radiographic axial spondyloarthritis, and plaque psoriasis [1.3.1, 1.3.3]. The medication is administered via subcutaneous injection, meaning it's delivered just under the skin [1.2.2].
Before starting treatment, your healthcare provider must screen you for tuberculosis (TB), as Cimzia can lower your immune system's ability to fight infections [1.3.3, 1.4.3]. Because of its effect on the immune system, Cimzia carries a boxed warning for the risk of serious infections and certain cancers [1.3.3].
Step-by-Step Guide: How to Administer Cimzia Injection
Properly administering your Cimzia injection is crucial for safety and efficacy. A healthcare professional should instruct you on the proper technique before you attempt to do it yourself [1.3.2].
Step 1: Preparation
- Gather Supplies: You will need your Cimzia prefilled syringe, an alcohol swab, a dry cotton ball or gauze, and an FDA-cleared sharps disposal container [1.2.5, 1.5.2].
- Inspect the Syringe: Remove the syringe from its carton. Check the expiration date [1.2.2]. The liquid should be clear and colorless to yellow, without particles [1.2.4]. Do not use it if it's cloudy, discolored, or contains particles, or if the expiration date has passed [1.2.2].
- Warm to Room Temperature: Let the syringe sit at room temperature for about 15 to 30 minutes. Do not warm it in any other way, such as in a microwave or hot water [1.2.2]. Do not remove the needle cap until you are ready to inject.
- Wash Your Hands: Thoroughly wash your hands with soap and warm water [1.2.2].
Step 2: Choosing and Cleaning the Injection Site
- Select a Site: The recommended injection sites are the front of your thighs or your abdomen [1.4.4].
- Thighs: Use the top and outer parts of your thighs. Avoid the inner thighs or areas near the knee [1.4.2].
- Abdomen: Avoid the 2-inch area directly around your navel (belly button) [1.4.1].
- Rotate Sites: It is critical to rotate your injection sites with each dose. Each new injection should be at least one inch away from the previous site. Do not inject into skin that is tender, bruised, red, hard, or has scars or stretch marks [1.4.1, 1.4.3]. Keeping a log of your injection sites can help you remember where you last injected.
- Clean the Site: Use an alcohol swab to clean the chosen injection site in a circular motion. Allow the area to air dry completely before injecting [1.2.5, 1.4.2]. Do not touch the cleaned area again [1.2.1].
Step 3: Administering the Injection
- Remove the Needle Cap: Hold the syringe with the needle pointing up. You may see air bubbles; this is normal and there is no need to remove them [1.2.2]. Pull the plastic ring needle cover straight off [1.2.2]. Do not touch the needle.
- Pinch the Skin: With your other hand, gently pinch a fold of skin at the cleaned injection site [1.2.2].
- Insert the Needle: With a quick, dart-like motion, insert the full needle into the pinched skin at a 45-degree angle [1.2.2, 1.2.3].
- Inject the Medication: Once the needle is in, release the pinched skin [1.2.3]. Slowly push the plunger all the way down until the syringe is empty [1.2.2].
- Withdraw the Needle: Pull the needle straight out of the skin at the same angle it was inserted [1.2.3].
- After the Injection: Place a dry cotton ball or gauze pad over the site for a few seconds. Do not rub the area [1.2.2]. Minor bleeding or a small drop of liquid at the site is normal.
Step 4: Disposal and Storage
- Dispose of the Syringe: Immediately place the used syringe in an FDA-cleared sharps disposal container. Do not throw loose needles or syringes in the household trash [1.5.2].
- Store Unused Syringes: Store unused Cimzia syringes in their original carton in a refrigerator between 36°F and 46°F (2°C to 8°C) [1.5.2]. Protect them from light and do not freeze them. If necessary, syringes can be stored at room temperature (up to 77°F or 25°C) for a single period of up to 7 days, but they must be discarded if not used within that time and should not be put back in the refrigerator [1.5.2, 1.10.3].
Cimzia vs. Humira: A Quick Comparison
Cimzia and Humira (adalimumab) are both TNF blockers used for similar conditions, but they have some key differences [1.6.1, 1.6.3].
| Feature | Cimzia (certolizumab pegol) | Humira (adalimumab) |
|---|---|---|
| Active Drug | Certolizumab pegol [1.6.2] | Adalimumab [1.6.2] |
| Dosing Frequency | Typically every 2 or 4 weeks for maintenance [1.6.2] | Typically every 1 or 2 weeks [1.6.2] |
| Use in Children | Not approved for use in children [1.6.1] | Approved for certain conditions in children as young as 2 [1.6.2] |
| Pregnancy | Has minimal transfer across the placenta [1.6.3] | Crosses the placenta during the third trimester [1.6.3] |
| Room Temp Storage | Can be stored for a single period of up to 7 days [1.10.3] | Can be stored for up to 14 days [1.6.1] |
Conclusion
Learning how to administer your Cimzia injection correctly is a vital part of managing your autoimmune condition. Following these steps carefully—from preparation and site rotation to proper injection technique and disposal—helps ensure the medication is delivered safely and effectively. Always consult with your healthcare provider if you have any questions or concerns about your treatment, side effects, or the injection process itself. For additional guidance, refer to the resources provided by the manufacturer.
