Introduction to Tesamorelin and Self-Injection
Tesamorelin is a synthetic peptide used to treat excess abdominal fat associated with HIV-associated lipodystrophy. It is administered via subcutaneous injection, which is an injection into the fatty tissue just under the skin. While your healthcare provider will offer initial training, understanding and correctly following the procedure at home is essential for patient safety and medication efficacy.
Step-by-Step Guide to Tesamorelin Injection
Gathering Your Supplies
Before you begin, assemble all necessary materials on a clean, flat, and well-lit surface. This ensures a smooth and sanitary process. You will need the following items from your medication kit:
- The tesamorelin vial (powder)
- The sterile water vial (diluent)
- Two sterile syringes with needles (one for mixing, one for injection)
- Alcohol swabs
- An approved sharps container for disposal
The Reconstitution Process
Tesamorelin must be mixed with the diluent before use. It is critical to follow the instructions for the specific formulation prescribed, such as EGRIFTA SV or EGRIFTA WR, as reconstitution steps differ significantly.
- Inspect the Vials: Ensure both the tesamorelin and diluent vials are intact. Check the expiration dates and confirm the diluent is clear and colorless.
- Prepare the Vials: Clean the rubber tops of both vials with separate alcohol swabs and allow them to air dry completely.
- Draw the Diluent: Using a sterile syringe, draw the specified amount of sterile water. Be mindful of air bubbles; tap the syringe to move them to the top and push them out.
- Add Diluent to Tesamorelin: Insert the needle into the tesamorelin vial. Slowly inject the sterile water by aiming the needle at the side of the vial to minimize foaming.
- Mix Gently: Do not shake the vial, as this can degrade the medication. Instead, gently roll the vial between your hands for about 30 seconds until the powder is fully dissolved and the solution is clear and colorless.
- Withdraw the Dose: Using the second, fresh syringe and needle, withdraw the correct amount of the reconstituted solution as prescribed by your healthcare provider.
Administering the Injection
- Prepare the Site: Select a site on your abdomen, at least two inches away from your navel. Use a new alcohol swab to clean the skin where you will inject and let it dry.
- Pinch the Skin: Gently pinch a fold of skin between your thumb and index finger to create a firm injection area.
- Insert the Needle: Hold the syringe like a pen and insert the needle into the pinched skin at a 90-degree angle.
- Inject the Medication: Slowly depress the plunger to inject all the solution.
- Withdraw the Needle: Once the syringe is empty, pull the needle straight out. Release the pinched skin.
Safe and Effective Injection Practices
- Rotate Injection Sites: Daily rotation of the injection site is crucial to prevent scarring, bruising, and skin irritation. A helpful method is to mentally divide your abdomen into four quadrants, using a different quadrant each day.
- Disposal of Sharps: Place all used needles and syringes immediately into an FDA-approved, puncture-resistant sharps container. Never throw loose sharps into the regular trash.
- Visual Inspection: Always inspect the reconstituted solution before each injection. Do not use if it is cloudy, discolored, or contains particles.
Avoiding Common Mistakes
- Incorrect Reconstitution: Never shake the vial. Always roll gently to mix.
- Sharing Needles: Never share needles or syringes with anyone, as this risks transmitting infectious diseases.
- Injecting into Damaged Skin: Avoid injecting into areas with scar tissue, bruises, hard bumps, or irritated skin.
- Freezing Reconstituted Solution: Never freeze or refrigerate the reconstituted solution unless specifically indicated by the manufacturer, which is rare for the single-use formulations.
Comparison Table: EGRIFTA SV vs. EGRIFTA WR Reconstitution
| Feature | EGRIFTA SV | EGRIFTA WR |
|---|---|---|
| Dose Format | Daily, single-use vial | Weekly, multi-dose vial |
| Diluent Volume | 0.5 mL Sterile Water for Injection | 1.3 mL Bacteriostatic Water for Injection |
| Storage After Reconstitution | Must be used immediately; discard any unused solution. | Stable for 7 days at room temperature (20-25°C), protected from light. |
| Mixing Method | Gently roll the vial between hands for 30 seconds. | Swirl gently to mix all powder and liquid; do not shake. |
Conclusion
By following this guide, you can confidently and safely administer your tesamorelin injections at home. Remember to pay close attention to the specific reconstitution instructions for your product, rotate injection sites regularly, and always dispose of sharps properly. Consistency and adherence to proper technique are key to both the safety and effectiveness of your treatment. For more detailed instructions, refer to the manufacturer's official guide, such as the FDA-approved Instructions for Use.
This article is for informational purposes only and should not replace advice from a qualified healthcare professional. Always consult your doctor or pharmacist regarding specific instructions for your medication.
