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Browse medication monographs, dosing guides, contraindications, interactions, and pharmacology-focused articles.

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Why should you avoid beta-blockers? Understanding the risks and contraindications

According to a 2021 meta-analysis published in *Hypertension*, the long-held belief that beta-blockers cause depression was not supported by evidence from double-blind, randomized controlled trials. However, there are still several important reasons **why you should avoid beta-blockers** in certain medical situations, from specific health conditions to potential adverse effects that require careful management.

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Who should avoid ramipril?

In 2023, ramipril was one of the most prescribed medications in the United States, with over 2 million prescriptions [1.2.2]. However, it's not suitable for everyone. Understanding who should avoid ramipril is crucial for patient safety and efficacy [1.3.2].

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What is Controlled Hypotension During Spine Surgery?

Controlled hypotension can significantly reduce intraoperative blood loss and the need for blood transfusions during major spinal surgeries. This medically induced state of lower-than-normal blood pressure is a carefully managed procedure performed by an anesthesia team to improve surgical conditions and enhance patient outcomes.

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Norepinephrine: What is the First Drug of Choice for Hypotension?

For patients in septic shock, immediate treatment with a vasopressor is critical after fluid resuscitation to correct hypotension. While the specific choice depends on the underlying cause, norepinephrine is widely considered the first drug of choice for hypotension in many acute and severe conditions. This guideline reflects its potent and reliable effects on blood pressure and is a cornerstone of critical care practice.

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What are the guidelines for Epogen hemoglobin levels?

Medical trials have shown that targeting hemoglobin levels higher than a certain threshold with erythropoiesis-stimulating agents (ESAs) like Epogen can increase the risk of serious cardiovascular events and stroke in patients with chronic kidney disease. These significant risks have reshaped the modern guidelines for Epogen hemoglobin therapy, moving the focus from aggressive normalization to conservative management aimed at reducing the need for blood transfusions.

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