Can Amazon One Medical prescribe antidepressants?

October 11, 2025 •

4 min read

According to One Medical, around 19% of U.S. adults live with a mental health condition, but many don't receive treatment. The answer to "Can Amazon One Medical prescribe antidepressants?" is yes, its primary care providers can, as part of an integrated approach to mental health care.

Quick Summary

Amazon One Medical primary care providers can evaluate, diagnose, and prescribe antidepressants for patients with mental health concerns. They also offer ongoing medication management and provide referrals to specialists like psychiatrists when more complex care is needed.

Key Points

PCPs Can Prescribe: One Medical's primary care providers are authorized to prescribe and manage antidepressant medications when clinically appropriate.
Referrals for Specialists: One Medical does not employ psychiatrists but can provide referrals to trusted specialists for more complex or specialized mental health care.
Membership vs. Pay-per-Visit: The scope of mental health services varies between the membership plan and the pay-per-visit option, especially concerning new prescriptions.
Medication Management Included: Membership-based care includes ongoing medication management, such as dose adjustments and monitoring.
Holistic Approach: One Medical integrates mental health care into its primary care model, recognizing the connection between physical and mental well-being.

Your Primary Care Provider's Role in Mental Health

Many people are unaware that their primary care provider (PCP) can be a crucial first point of contact for mental health concerns, including depression. The standard healthcare model often separates mental health from physical care, creating barriers to treatment. One Medical, however, takes an integrated approach, viewing mental and physical health as deeply interconnected. This means a PCP can effectively screen, diagnose, and treat common mental health issues such as anxiety and depression. By starting with your PCP at One Medical, you can discuss symptoms, explore potential causes, and develop a personalized treatment plan in a setting that's often more accessible and less stigmatizing than seeking a specialist directly.

The Process of Getting an Antidepressant Prescription

If you and your One Medical provider determine that medication is appropriate for your depression, they are fully qualified to write a prescription. The process typically involves a comprehensive evaluation during a mental health visit, which can be done in person or remotely via video chat. Your provider will discuss your health history, symptoms, and lifestyle to collaborate on a treatment plan. They will also consider potential drug interactions with other medications you may be taking.

During this evaluation, One Medical providers can prescribe and manage a wide range of antidepressants, including:

Selective Serotonin Reuptake Inhibitors (SSRIs): Such as Prozac (fluoxetine), Zoloft (sertraline), and Lexapro (escitalopram).
Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs): Including Cymbalta (duloxetine) and Effexor XR (venlafaxine).
Atypical Antidepressants: Like Wellbutrin (bupropion).
Tricyclic Antidepressants (TCAs) and Monoamine Oxidase Inhibitors (MAOIs): Managed when appropriate, though typically reserved for cases where other treatments have not been effective.

One Medical Membership vs. Pay-per-Visit for Mental Health

One Medical offers different access models that affect the scope of mental health services available. The membership model includes comprehensive care, while the Pay-per-visit option has distinct limitations regarding antidepressant prescriptions.


Feature	One Medical Membership	One Medical Pay-per-Visit
Initiate New Prescription	Yes, primary care providers can initiate and manage new antidepressant prescriptions after a full evaluation.	No, providers cannot initiate a new antidepressant prescription.
Prescription Renewal	Yes, renewals are handled as part of ongoing medication management within the membership plan.	Yes, renewals are available for certain existing antidepressant prescriptions for a limited supply (e.g., 30 days) and for a fixed number of times (e.g., one or two renewals per year).
Medication Management	Yes, PCPs offer ongoing reviews, monitoring, and dose adjustments as part of your personalized treatment plan.	No, providers will not adjust medication or offer ongoing management. This is for renewals only.
Specialist Referrals	Yes, PCPs can provide coordinated referrals to psychiatrists or therapists if more specialized care is needed.	No, this service is not part of the pay-per-visit model.
Cost Structure	Requires an annual membership fee plus any applicable co-pays for scheduled visits.	A flat, out-of-pocket fee per visit, with no membership required.

When a Specialist Referral is Needed

While One Medical PCPs can effectively manage common mental health issues, they are not psychiatrists or psychotherapists. For complex cases, severe mental health conditions, or if a patient requires more specialized psychiatric evaluation or therapy, a referral to an outside specialist is necessary. One Medical has a curated network of trusted therapists and psychiatrists and will facilitate a warm handoff to ensure continuity of care. This integrated approach ensures that patients get the right level of care for their specific needs.

Mindset by One Medical for Additional Support

For businesses, and in some markets for individuals, One Medical offers "Mindset," an additional suite of behavioral health services. This can include virtual therapy and coaching, wellness series, and enhanced care coordination. Mindset by One Medical is designed to provide rapid, affordable access to mental health support.

Conclusion: An Accessible and Integrated Path to Care

In summary, yes, Amazon One Medical can prescribe antidepressants through its primary care providers, making it a highly accessible option for mental health treatment. This is part of a larger, integrated care model that prioritizes both mental and physical health. Patients can be evaluated and receive new prescriptions as part of a comprehensive treatment plan through a membership, while the Pay-per-visit option is limited to renewals for existing prescriptions. If specialized psychiatric care is required, One Medical's providers can refer you to a trusted network of specialists, ensuring you get the comprehensive support you need. The approach focuses on holistic well-being, starting with a supportive and familiar provider who can quarterback your entire health journey.

For more information on different types of antidepressants and their functions, you can visit the Mayo Clinic's detailed guide.

Frequently Asked Questions

Yes, if you are a One Medical member. A primary care provider can conduct a comprehensive evaluation and, if medically appropriate, write an initial prescription for antidepressants as part of your overall treatment plan.

Yes, One Medical promotes a holistic approach. Its providers can recommend lifestyle changes, provide referrals to therapists or counselors, and, in some markets, connect you to virtual therapy and coaching programs.

No. The Pay-per-visit model is limited to prescription renewals for certain existing psychotropic medications. It cannot be used to start a new antidepressant or adjust an existing dose.

No, One Medical does not employ psychiatrists directly. Its primary care providers handle general mental health needs, and they will refer you to an external specialist, such as a psychiatrist, if higher-level care is required.

For members, One Medical's PCPs provide ongoing medication management, including monitoring your symptoms, discussing potential side effects, and adjusting your dosage as needed.

One Medical providers can prescribe and manage a wide range of antidepressants, including SSRIs (like Zoloft, Lexapro), SNRIs (like Cymbalta, Effexor XR), atypical antidepressants (like Wellbutrin), and others.

You can book a mental health visit, either in-person or as a remote video visit, through the One Medical app. This allows you to talk with a primary care provider about your concerns.