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Can Antidepressants Make You Feel Spaced Out? Understanding the Side Effect

6 min read

It is quite common to feel "spacey" or emotionally blunted when starting antidepressants; research suggests that between 40-60% of patients taking SSRIs experience this emotional dulling. While unsettling, the spaced out feeling is often a temporary side effect of your brain's adjustment to the medication.

Quick Summary

This article explores why antidepressants can cause feelings of being spaced out, explaining the roles of emotional blunting, brain fog, and the brain's adjustment phase. It details strategies for managing these side effects and highlights when to consult a healthcare provider for a potential dose adjustment or medication change.

Key Points

  • Common Side Effect: Feeling spaced out, often described as emotional blunting or brain fog, is a common side effect, especially when starting antidepressants.

  • Brain Adjustment: This feeling is frequently due to your brain adjusting its neurotransmitter levels during the first few weeks of treatment and may resolve over time.

  • Multiple Causes: The spaced out sensation can stem from emotional blunting (flattened feelings), brain fog (cognitive impairment), and in some cases, depersonalization or derealization.

  • Doctor Consultation is Key: If the feeling is bothersome or persistent, it is important to talk to your healthcare provider, who can discuss adjusting the dosage or switching medications.

  • Lifestyle Can Help: Incorporating lifestyle changes such as regular exercise, prioritizing sleep, and practicing mindfulness can help mitigate the side effects.

  • Do Not Stop Abruptly: Never stop or change your medication without speaking to your doctor first, as this can lead to withdrawal symptoms or a return of depressive symptoms.

In This Article

Understanding the Spaced Out Sensation

The feeling of being spaced out while on antidepressants is a common but often confusing experience for many individuals. It can manifest in several different ways, blurring the line between the medication's effects and the original symptoms of a mental health condition. This sensation is a complex side effect that can involve cognitive, emotional, and sometimes even dissociative changes.

Manifestations of a “Spacey” Feeling

  • Emotional Blunting: This is arguably the most common cause of feeling spaced out. Emotional blunting describes a state where feelings are dulled or flattened, so that you experience neither extreme highs nor lows. While this can be a welcome relief from overwhelming sadness, it can also leave you feeling apathetic or detached from things you once enjoyed. People report feeling "blah" or emotionally numb.
  • Brain Fog: This side effect is characterized by cognitive difficulties that can make thinking feel cloudy or fuzzy. Symptoms include trouble with concentration, forgetfulness, and a sense of mental haziness. Brain fog can make it challenging to perform complex tasks or follow conversations, contributing to the feeling of being detached from reality.
  • Depersonalization/Derealization: In some cases, the spaced out feeling can be more intense, bordering on depersonalization (feeling detached from your own body) or derealization (feeling that the world around you is unreal). While some research shows SSRIs can help treat these conditions, they can also trigger or exacerbate them in certain individuals.

The Pharmacology Behind the Perception

The root causes of feeling spaced out on antidepressants are still being researched, but the effects are closely tied to how these drugs alter brain chemistry.

How Neurotransmitters and Adjustment Play a Role

  • Initial Adaptation: When you first start an antidepressant, your brain goes through an adjustment period as it gets used to the new level of neurotransmitters. The feeling of being spacey is often most pronounced during the first few weeks of treatment and frequently subsides as your body adapts.
  • Serotonin and Reinforcement Learning: Selective serotonin reuptake inhibitors (SSRIs), the most commonly prescribed type of antidepressant, increase the level of serotonin in the brain. Recent research suggests this change can interfere with "reinforcement learning," a process where we learn from positive and negative feedback. This can reduce your sensitivity to rewards, leading to a diminished sense of pleasure and joy, which manifests as emotional blunting.
  • Sedative Properties: Some antidepressants, particularly older tricyclics (TCAs) and certain newer options, have sedative properties that can cause drowsiness and a "grogginess" that can be mistaken for feeling spaced out.

Is It the Medication or the Depression?

It's important to recognize that the feeling of being spaced out isn't always caused by the medication alone. Depression itself can cause cognitive changes, including brain fog, difficulty concentrating, and issues with memory. Separating the side effects of the medication from the residual symptoms of the underlying condition can be difficult and often requires careful observation and communication with a healthcare provider. A key difference can be the timing: if the fogginess begins or worsens shortly after starting the medication, it's more likely to be a side effect.

Comparison of Antidepressant Types and "Spaced Out" Feelings

Antidepressant Class Typical Side Effects Likelihood of Emotional Blunting / Brain Fog Notes
SSRIs (e.g., Prozac, Zoloft) Emotional blunting, sexual dysfunction, nausea, sleep problems High Most commonly associated with emotional blunting due to their specific action on serotonin.
SNRIs (e.g., Cymbalta, Effexor) May have fewer cognitive side effects than SSRIs for some patients Moderate Affect both serotonin and norepinephrine; some find they cause less blunting.
NDRIs (e.g., Wellbutrin) Less likely to cause blunting, more stimulating, sexual side effects are less common Low Primarily affect norepinephrine and dopamine, and are often used as an alternative for those sensitive to blunting.
TCAs (e.g., Elavil) Can cause drowsiness, dry mouth, dizziness, constipation Moderate to High Older class of antidepressants, can cause significant grogginess.

Coping with the Feeling of Being Spaced Out

If you are experiencing a persistent spaced out feeling, it is crucial to communicate with your doctor. Do not stop taking your medication abruptly, as this can cause unpleasant withdrawal symptoms. Here are some strategies that your healthcare provider might discuss with you:

  • Adjust the Dosage: A lower dose may sometimes alleviate or lessen side effects. Your doctor can determine if this is a safe and effective option.
  • Change Medications: There are many different types of antidepressants available. If one is causing bothersome side effects, another may be a better fit. Discussing the pros and cons of switching to an SNRI or NDRI may be productive.
  • Adopt Lifestyle Changes: Incorporating healthy habits can help combat cognitive and emotional side effects.
    • Exercise regularly: Physical activity increases blood flow to the brain and can improve cognitive function.
    • Prioritize sleep: Ensure you get 7-9 hours of quality sleep per night.
    • Manage stress: Techniques like yoga, meditation, and deep breathing can be beneficial.
    • Follow a healthy diet: Nutrient-rich foods can support brain health.
  • Practice Mindfulness and Cognitive Training: Engaging in mindfulness exercises can help you stay present and absorb experiences, broadening your emotional range. Cognitive training with puzzles or memory games can also sharpen your focus.
  • Give it Time: For many, the spaced out feeling is temporary and improves as the brain fully adjusts to the medication. Patience can be key during the initial phase of treatment.

Conclusion: Navigating Side Effects with Medical Guidance

Feeling spaced out is a legitimate and often distressing side effect of certain antidepressants, most notably SSRIs. This can be caused by emotional blunting, brain fog, or a temporary adjustment period as the medication takes effect. The good news is that for many, this feeling is manageable and not permanent. The key is to maintain open communication with your healthcare provider. The ultimate goal is to find a treatment plan that effectively manages your mental health condition with the most tolerable side effects. Never make changes to your medication regimen without professional medical advice.

For more information on managing antidepressant side effects, you can consult reputable sources like the Mayo Clinic's guide on coping with side effects. Remember, finding the right medication and balance for your unique needs is a collaborative process that may require some trial and error.


Disclaimer: The information in this article is for informational purposes only and does not constitute medical advice. Please consult with a qualified healthcare professional regarding any medical conditions or before making any decisions related to your health or treatment. Do not stop taking any medication without first speaking to your doctor. All medical information is provided without warranty or guarantee of any kind.

Frequently Asked Questions

How long does the spaced out feeling from antidepressants typically last?

The spaced out feeling, especially when starting a new antidepressant, often lasts for the first few weeks as your brain adjusts. For some, it may persist as long as they are on the medication, but many find it improves over time or with a change in dosage or medication type.

Is feeling spaced out the same as feeling emotionally numb?

Feeling spaced out is often a broader term that can include emotional numbness, also known as emotional blunting. Emotional blunting is the dulling of emotions, while feeling spaced out can also encompass cognitive difficulties like brain fog or a general sense of mental detachment.

Can my depression itself cause me to feel spaced out?

Yes, depression can independently cause cognitive issues such as brain fog, problems with concentration, and memory lapses, which can contribute to a spaced out feeling. A doctor can help determine if your symptoms are related to the depression or the medication.

Are some antidepressants less likely to make you feel spaced out?

Yes, some antidepressant classes, such as norepinephrine and dopamine reuptake inhibitors (NDRIs) like bupropion (Wellbutrin), are less commonly associated with the emotional blunting and sedation that can cause a spaced out feeling compared to SSRIs.

What should I do if the spaced out feeling doesn't go away?

If the feeling persists for more than a few weeks and is bothersome, you should talk to your doctor. They may suggest adjusting your dosage, switching to a different medication, or adding another medication to your regimen.

Can lifestyle changes help with the spaced out feeling?

Yes, adopting healthy lifestyle habits can be beneficial. Regular exercise, a balanced diet, proper sleep hygiene, and stress management techniques like mindfulness can help improve cognitive function and mood.

Is it safe to stop taking my medication if I feel too spaced out?

No, you should never stop taking an antidepressant suddenly without consulting your doctor. Abruptly discontinuing the medication can cause withdrawal symptoms or lead to a relapse of your depression. A doctor can guide you on how to taper off the medication safely if necessary.

Frequently Asked Questions

The spaced out feeling often lasts for the first few weeks as your brain adjusts to the new medication. For many, it lessens over time, but if it persists and is bothersome, you should consult your doctor.

Feeling spaced out can encompass emotional numbness (blunting), a common antidepressant side effect. It can also include brain fog, which affects concentration and memory, creating a broader sense of mental detachment.

Yes, depression can independently cause cognitive issues like brain fog and difficulty concentrating. Your doctor can help determine if your symptoms are related to the depression or the medication.

Yes, antidepressants that affect norepinephrine and dopamine, like bupropion (Wellbutrin), are less commonly associated with the emotional blunting and cognitive side effects of SSRIs. Your doctor can discuss alternatives if you are sensitive to these side effects.

If the feeling persists for more than a few weeks and is bothersome, you should talk to your doctor. They may suggest adjusting your dosage, switching to a different medication, or adding another medication to your regimen.

Yes, healthy lifestyle habits can help. Regular exercise, a balanced diet, proper sleep hygiene, and stress management techniques like mindfulness can help improve cognitive function and mood.

No, you should never stop taking an antidepressant suddenly without consulting your doctor. Abrupt discontinuation can cause withdrawal symptoms or a relapse of your depression. A doctor can guide you on a safe tapering process if necessary.

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.