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Can Steroid Shots Cause Headaches? Understanding the Link

4 min read

Headaches are a known, though not the most common, side effect of corticosteroid injections, also referred to as cortisone shots. While often temporary and mild, the underlying causes for a headache after a steroid shot can range from systemic effects to a rare but serious complication called a post-dural puncture headache. This article explores how and why steroid shots can cause headaches and provides guidance on managing symptoms.

Quick Summary

Steroid shots can trigger headaches through systemic side effects like insomnia or temporary blood sugar changes, or rarely, a post-dural puncture headache from a spinal injection. Understanding the cause is key to effective management, with treatment options varying from rest and OTC pain relievers to specialized care for severe cases.

Key Points

  • Headaches are a potential side effect: Corticosteroid injections, such as cortisone shots, are known to be able to cause headaches, though they are not the most common side effect.

  • Systemic effects can trigger headaches: Side effects like insomnia, temporary increases in blood sugar, and fluid retention can cause headaches through systemic disruption.

  • Epidural shots carry a risk of PDPH: A rare but serious risk with epidural steroid injections (ESIs) is a post-dural puncture headache (PDPH), caused by a CSF leak.

  • PDPH is positional: A headache that significantly worsens when sitting or standing and improves when lying down is a classic sign of PDPH.

  • Withdrawal can cause headaches: For patients on long-term steroids, abruptly stopping medication can lead to a withdrawal syndrome that includes headaches.

  • Management varies by cause: Treatment ranges from rest and OTC pain relievers for mild systemic headaches to specialized procedures like a blood patch for persistent PDPH.

  • Consult your doctor: It is essential to communicate with a healthcare professional about any new or severe headaches after a steroid shot, especially if you have had a spinal injection.

In This Article

Can Steroid Shots Cause Headaches?

Yes, steroid shots can cause headaches, and this is a recognized potential side effect of corticosteroid injections. While not every person will experience this, and it is less common than other side effects like pain or bruising at the injection site, it's important for patients to be aware of the possibility. The likelihood and type of headache can depend on the specific medication, the injection site, and individual patient factors. In some cases, such as with epidural steroid injections, the headache can be a signal of a more specific complication.

Understanding the Mechanisms: How Steroids Trigger Headaches

There are several distinct ways in which a steroid shot can lead to a headache, each with a different mechanism and level of severity. Differentiating between these causes is important for proper management.

Systemic Side Effects

Corticosteroid injections can cause systemic (body-wide) effects even when administered locally, which can indirectly lead to headaches. Some of these effects include:

  • Insomnia and mood changes: Steroids can disrupt sleep patterns and cause mood swings, and a lack of sleep is a well-known headache trigger.
  • High blood pressure: Steroids can cause a temporary increase in blood pressure, which is often associated with headaches.
  • Increased blood sugar: For individuals with or without diabetes, a corticosteroid shot can temporarily elevate blood glucose levels, which can also induce headaches.
  • Fluid retention: Water retention is a systemic side effect that can sometimes contribute to headaches.

Post-Dural Puncture Headache (PDPH)

This is a specific, though rare, and serious type of headache associated with epidural steroid injections (ESIs) into the spine. The mechanism is a cerebrospinal fluid (CSF) leak. The dura mater is the protective membrane surrounding the spinal cord. If the injection needle accidentally punctures this membrane, CSF can leak out. This reduces the pressure of the fluid cushioning the brain and spinal cord, causing a characteristic headache. Key features of a PDPH include:

  • It is positional, meaning it worsens significantly when sitting or standing and improves when lying down.
  • It can begin anytime within 24 to 48 hours after the injection, though it may take up to 12 days to appear.

Steroid Withdrawal

While less common with a single injection, abruptly stopping long-term corticosteroid medication can induce a withdrawal syndrome. Headaches are a recognized symptom of steroid withdrawal, accompanied by fatigue, muscle aches, and other symptoms. This is typically a concern for people on prolonged oral steroid courses, but systemic effects from injections could also contribute in some contexts.

Distinguishing Headache Types After a Steroid Shot

To help identify the potential cause of your headache, consider the following characteristics. Consulting a healthcare professional is essential for a proper diagnosis.

Feature Systemic/Non-positional Headache Post-Dural Puncture Headache (PDPH)
Onset Hours to days after injection Usually 24-48 hours after spinal injection, but can be later
Severity Often mild to moderate Can be very severe
Positionality Not usually affected by body position Worsens when sitting or standing; improves when lying down
Associated Symptoms Insomnia, flushing, increased appetite, temporary blood sugar changes Nausea, neck stiffness, hearing changes, visual disturbances
Location of Injection Any injection site, but more likely with larger doses or systemic absorption Exclusively after epidural steroid injections into the spine
Duration Typically resolves within a few days Can persist for weeks without treatment

Management and Treatment of Steroid-Induced Headaches

Treatment depends on the underlying cause and severity. For systemic headaches, simple at-home care is often sufficient, but for PDPH, medical intervention may be necessary.

For systemic headaches:

  • Over-the-counter (OTC) pain relievers: Medications like acetaminophen (Tylenol) may be recommended for mild headaches. It's wise to consult your doctor before taking NSAIDs like ibuprofen, especially if you have heart conditions or take blood thinners, as steroids and NSAIDs can increase risks.
  • Rest and hydration: Ensuring adequate rest and drinking plenty of fluids can help mitigate headaches triggered by side effects like insomnia or dehydration.
  • Monitor blood sugar: For those with diabetes, careful monitoring of blood sugar is important, as management of hyperglycemia can help resolve related headaches.

For a suspected PDPH (seek medical advice):

  • Conservative treatment: Mild PDPH may improve with rest, hydration, and caffeine, which can help increase intracranial pressure.
  • Epidural blood patch: If the headache is severe and persistent, a procedure called an epidural blood patch may be performed. A small amount of your own blood is injected into the epidural space to clot and seal the CSF leak, providing rapid relief.
  • Inform your doctor: Always contact your healthcare provider if you experience a positional headache or severe headache after a spinal injection.

Conclusion

While a headache after a steroid shot is not an everyday occurrence, it is a possibility that patients should be aware of. The cause can range from mild, systemic side effects like insomnia or blood pressure fluctuations to the rare but serious complication of a post-dural puncture headache following a spinal injection. Most headaches related to systemic effects are temporary and can be managed with rest, hydration, and OTC pain relievers. However, if you experience a severe, positional headache after a spinal injection, prompt communication with your doctor is crucial to address a potential CSF leak. Patients should always have an open dialogue with their healthcare provider about any side effects they experience following a steroid injection to ensure proper care and management.

Visit the FDA website for more information on potential side effects and drug safety.

Frequently Asked Questions

Headaches are not the most common side effect of a cortisone shot, and a study on ankle joint injections showed no reported headaches among the side effects. The risk of a specific type of headache (PDPH) following a spinal epidural is also low, occurring in less than 1% of patients with modern techniques.

A steroid shot can cause a general, non-positional headache from systemic side effects or, in the case of a spinal epidural, a specific positional headache known as a post-dural puncture headache (PDPH).

Headaches from systemic side effects are typically short-lived, lasting a few hours to a few days. A post-dural puncture headache (PDPH) can last longer, potentially weeks, and requires medical attention if it persists.

Yes, for mild headaches potentially caused by systemic side effects, over-the-counter pain relievers like acetaminophen (Tylenol) may be recommended. Always consult with your doctor before taking NSAIDs like ibuprofen, especially if you have other health conditions.

You should contact your doctor if you experience a headache that is severe, persistent, or accompanied by other symptoms like vision changes or fever. It is especially important to seek medical advice for a severe, positional headache after an epidural steroid injection.

Yes, for individuals prone to migraines, the systemic effects of a steroid shot, such as insomnia or blood pressure fluctuations, could potentially trigger a migraine episode.

A PDPH is a rare complication of a spinal epidural steroid injection where the needle accidentally punctures the dura mater, causing a leak of cerebrospinal fluid (CSF). This lowers the pressure around the brain, causing a headache that worsens when upright and improves when lying down.

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.