Understanding Bonine and Dramamine
Motion sickness is a common disturbance of the inner ear that is caused by repeated motion. It can turn a pleasant journey by car, boat, or plane into a miserable experience characterized by nausea, dizziness, and vomiting [1.6.1]. To combat these symptoms, many travelers turn to over-the-counter (OTC) medications like Bonine and Dramamine.
These drugs are popular because of their effectiveness, but understanding their active ingredients and how they work is crucial for using them safely. While they serve the same purpose, they are not identical.
Active Ingredients: The Core Difference
The primary distinction between these two medications lies in their active ingredients:
- Bonine's active ingredient is meclizine hydrochloride [1.3.1].
- Dramamine's Original Formula contains dimenhydrinate [1.3.1].
It is important to note that the Dramamine brand offers multiple formulations. For instance, 'Dramamine All Day Less Drowsy' contains meclizine, the same active ingredient as Bonine [1.9.2, 1.9.4]. For the purpose of this article, "Dramamine" refers to the original formula with dimenhydrinate.
Both meclizine and dimenhydrinate belong to a class of drugs called first-generation antihistamines [1.8.1]. Their effectiveness against motion sickness stems from their ability to block H1 histamine receptors and their anticholinergic properties, which inhibit signals to the part of the brain that controls nausea and vomiting (the vomiting center) [1.8.1, 1.8.4].
The Risks of Combining Bonine and Dramamine
So, can you take Bonine and Dramamine together? The medical advice is clear: No, you should not combine them [1.2.1, 1.4.2].
Because both meclizine (Bonine) and dimenhydrinate (Dramamine) are first-generation antihistamines, taking them at the same time is equivalent to taking a double dose of the same type of medication [1.4.5]. This significantly increases the risk and severity of side effects. This is known as an additive effect, where the combined impact is greater than the individual effects [1.4.3].
Increased Side Effects
Combining these two drugs can amplify their anticholinergic and sedative effects [1.4.1]. Potential increased side effects include:
- Severe Drowsiness and Dizziness: Both medications cause drowsiness, and combining them can lead to significant impairment, making activities that require mental alertness, like driving, extremely dangerous [1.2.1, 1.4.1].
- Dry Mouth, Eyes, and Nose: The anticholinergic properties that help with nausea also dry out mucous membranes [1.5.2].
- Blurred Vision: This is another common anticholinergic side effect that can be intensified [1.2.1].
- Confusion and Memory Problems: The central nervous system-depressant effects can be more pronounced, especially in older adults [1.4.1, 1.4.3].
- Urinary Retention: Difficulty urinating can occur and may be worsened by the combination [1.5.5].
- Constipation: The slowing effect on the digestive system can be enhanced [1.2.2].
- Increased Heart Rate (Tachycardia) and Flushing: These are also potential signs of excessive anticholinergic effects [1.4.1].
The risk of these adverse effects is particularly high in the elderly and individuals with pre-existing conditions like glaucoma, an enlarged prostate, or breathing problems such as asthma or emphysema [1.4.1, 1.10.4].
Comparison: Bonine vs. Dramamine
Choosing one medication over the other depends on individual needs regarding duration, side effects, and age. Here is a direct comparison to help you decide which is better for your situation.
| Feature | Bonine (Meclizine) | Dramamine Original (Dimenhydrinate) |
|---|---|---|
| Active Ingredient | Meclizine HCl 25 mg [1.3.1] | Dimenhydrinate 50 mg [1.3.1] |
| Dosing Frequency | Once every 24 hours [1.3.3] | Every 4-6 hours [1.3.3] |
| Onset Time | Take 1 hour before travel [1.3.3] | Take 30-60 minutes before travel [1.3.3] |
| Drowsiness Level | Generally considered less drowsy [1.7.2, 1.9.5] | Causes more significant drowsiness [1.7.1] |
| Age Use | Adults and children 12+ [1.7.2] | Adults and children 2+ [1.7.2] |
| Duration of Action | Up to 24 hours [1.3.3] | 4 to 8 hours [1.7.2] |
Which Should You Choose?
- Choose Bonine (Meclizine) if you need long-lasting, 24-hour protection and want a less drowsy option for a long trip [1.7.2]. It is often preferred for multi-day journeys like cruises.
- Choose Dramamine (Dimenhydrinate) if you need faster-acting relief for a shorter trip and are not concerned about drowsiness [1.7.2]. It is also the only option of the two suitable for children between the ages of 2 and 12 [1.7.3].
Safer Alternatives and Best Practices
Instead of combining medications, consider these safer strategies to manage motion sickness:
- Choose One and Stick With It: Select either Bonine or Dramamine based on the comparison above and follow the dosage instructions carefully.
- Look for Non-Drowsy Formulas: Dramamine offers a "Non-Drowsy" version that uses ginger, a natural root known to help with nausea, instead of an antihistamine [1.3.1].
- Consider Scopolamine Patches: For severe or prolonged motion sickness, a prescription scopolamine patch may be a better option. It's applied behind the ear and lasts for up to three days [1.3.4].
- Try Non-Pharmacological Methods:
- Acupressure Bands: These wristbands apply pressure to a specific point on the wrist, which may help relieve nausea for some individuals.
- Ginger: Consuming ginger in the form of capsules, chews, or tea can help settle the stomach [1.8.4].
- Behavioral Adjustments: Look at the horizon, get fresh air if possible, and avoid reading or looking at screens [1.6.4].
- Avoid Alcohol: Drinking alcohol can significantly increase the drowsiness caused by either Bonine or Dramamine and should be avoided [1.2.3].
Conclusion
It is unsafe to take Bonine and Dramamine together. Both are first-generation antihistamines, and combining them significantly increases the risk of serious side effects like extreme drowsiness, blurred vision, and confusion [1.2.1, 1.4.1]. The best course of action is to choose one medication based on your specific needs—Bonine for its longer duration and less drowsy effect, or Dramamine for its faster onset and suitability for children. Always read the active ingredients on the label, especially since different products under the same brand name can contain different drugs [1.9.2]. When in doubt, consulting a doctor or pharmacist is the safest way to ensure you are managing your motion sickness effectively and without unnecessary risk.
Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with a healthcare professional before starting or combining any medications.
