Category: Antibiotic resistance

Most anaerobic bacteria are intrinsically resistant to aminoglycoside antimicrobial agents due to their lack of oxygen-dependent transport systems required for drug uptake. This poses significant challenges for treatment, highlighting the critical need to identify **what bacteria are resistant to aminoglycosides** before prescribing.

The most clinically significant mechanism of macrolide resistance involves enzymes encoded by *erm* (erythromycin ribosome methylase) genes [1.4.1]. This article details which enzyme is responsible for macrolide resistance and explores other contributing biochemical pathways.