Category: Autoimmune disease management

While low-dose methotrexate is generally well-tolerated for conditions like rheumatoid arthritis, affecting a small percentage of patients, neurotoxicity is a rare but recognized side effect. In rare cases, this can manifest as tingling or numbness, prompting concerns about whether **methotrexate can cause neuropathy in the feet**.

According to the Arthritis Foundation, approximately 90% of rheumatoid arthritis (RA) patients use methotrexate at some point in their treatment. Knowing how do you wean off of methotrexate is a crucial step for many patients, whether due to achieving remission, experiencing intolerable side effects, or planning for pregnancy.