Category: Cannabis science

While the average THC content in illicit cannabis quadrupled between 1995 and 2022, determining what strain gets you higher is a complex interplay of cannabinoids, terpenes, and individual biology, not just the THC percentage alone. This multifaceted interaction, known as the 'entourage effect', is the key to understanding a strain's true potency.

Over 100 cannabinoids have been identified in the cannabis plant, but the vast majority exist only in trace amounts. These lesser-known compounds, known as minor or **what are the rarest cannabinoids**, are emerging as the next frontier in cannabis research, offering unique effects that differ significantly from common THC and CBD.

THC is highly lipid-soluble, meaning it binds to fat molecules in your body, which can significantly prolong its effects and detection window [1.3.5, 1.3.4]. Understanding the pharmacology behind cannabis helps explain **why does being high last so long?**