Category: Drug discontinuation

The brand name medication Twynsta was discontinued in the U.S. not for safety or effectiveness reasons, but as a manufacturer's business decision. This means that while the brand is no longer on pharmacy shelves, the combined generic version of its active ingredients, telmisartan and amlodipine, remains widely available.

In 2008, the European Medicines Agency (EMA) recommended suspending the marketing of carisoprodol-containing products throughout Europe after a review found its risks outweighed its benefits. This marked a significant turn for the muscle relaxant and provides important context for understanding why was carisoprodol discontinued in many regions and reclassified in others.

Despite being a widely recognized brand name for the muscle relaxant cyclobenzaprine, Flexeril was discontinued in 2023, leaving many patients confused about their medication. The primary reason for the discontinuation was market economics, not safety concerns, as the patent expired and cheaper generic versions flooded the market.