How do COX-2 inhibitors affect the heart?
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5 min read
While developed to reduce gastrointestinal side effects, early clinical trials revealed that COX-2 inhibitors, particularly rofecoxib (Vioxx), significantly increase the risk of adverse cardiovascular events. This discovery raised urgent questions about how do COX-2 inhibitors affect the heart and led to re-evaluations of all anti-inflammatory drugs.
