Category: Longevity

While most know metformin as a prescription drug for type 2 diabetes, a 2014 observational study surprisingly found that diabetic patients on metformin showed a lower mortality risk than non-diabetic controls. This unexpected finding ignited widespread interest in its anti-aging potential, leading prominent longevity experts to incorporate metformin into their personal regimens.

Despite widespread interest, longevity expert Dr. David Sinclair has stated publicly that he does not endorse any specific NMN brands. This decision is rooted in his ethical stance as a Harvard researcher, rather than a lack of belief in Nicotinamide Mononucleotide (NMN) itself.

Initially discovered in soil from Easter Island (Rapa Nui) in the 1970s, the drug rapamycin is typically used as a powerful immunosuppressant to prevent organ rejection in transplant patients. However, groundbreaking research in model organisms has raised the fascinating question: **What transplant drug slows aging?**

In July 2024, NPR reported on a clinical trial testing rapamycin, a generic drug known to extend lifespan in animals, for its potential anti-aging effects in humans. The 'NPR longevity drug' primarily refers to **rapamycin**, though NPR has covered other compounds, such as metformin and senolytics, underscoring the growing field of pharmacological interventions aimed at delaying age-related decline.

Despite decades of research, no single drug is currently approved by the FDA with proven anti-aging effects in humans. The scientific community, however, is actively investigating various compounds, exploring the question of what drug slows aging and its related diseases.

NAD+ levels in the human body can decline by over 50% by middle age, contributing to fatigue and cognitive decline. **What is NAD+ nasal spray?** It's an innovative, non-invasive method designed to replenish the vital coenzyme Nicotinamide Adenine Dinucleotide (NAD+) directly into the body's circulation through the nasal passages.

While primarily a type 2 diabetes medication, a 2014 observational study showed that diabetic patients taking metformin had a lower mortality risk than non-diabetic controls. This intriguing finding helps explain **why does David Sinclair take metformin?** as part of his regimen for healthy aging.

By middle age, the body’s NAD+ levels can drop to half their youthful state. This natural decline has spurred significant interest in precursors like NMN, as research explores what are the benefits of NMN for cellular health and healthy aging.

Resveratrol has long been celebrated for its potential anti-aging and cardioprotective properties, yet its effectiveness is hampered by remarkably low oral bioavailability, with less than 20% being absorbed in its active form. For this reason, the quest for what's better than resveratrol has led researchers to investigate compounds with superior pharmacological profiles that can deliver more pronounced health benefits.

Research indicates that NAD+ levels can decline by as much as 75% by age 40, making it critical to ask, 'How do I know if I am low in NAD?'. This decline is often linked to the signs of aging and various metabolic issues. Understanding the signs and seeking proper testing is the first step toward addressing potential deficiencies.