Category: Metabolic health

Over 43% of adults with diabetes have tried GLP-1 medications, according to a recent SBM article. The terms GLP-1 and Ozempic are frequently used interchangeably, yet they are not the same thing. Understanding the relationship between the naturally occurring hormone and the brand-name prescription drug is key to understanding their roles in managing type 2 diabetes and obesity.

The human body releases a natural gut hormone, glucagon-like peptide-1 (GLP-1), within minutes of food ingestion to help regulate blood sugar and appetite. Understanding what is GLP-1 also known as is essential for grasping the mechanism behind a powerful class of modern medications used for treating type 2 diabetes and obesity.

Up to 30% of patients experience gastrointestinal side effects like nausea and vomiting when starting semaglutide, highlighting the importance of a gradual approach to dosing. Exploring what are the benefits of small doses of semaglutide reveals it is a critical strategy for minimizing adverse reactions, improving patient adherence, and effectively managing metabolic health.

The active ingredient in Mounjaro, tirzepatide, is approximately 80% absorbed after subcutaneous injection. Understanding the drug's pharmacokinetic profile, including **how many days after injection does Mounjaro peak**, is crucial for managing treatment expectations, side effects, and overall efficacy.

Contrary to some concerns, scientific studies indicate that losartan therapy does not typically raise triglycerides; in fact, several reports show it can actually have a beneficial effect by lowering them. This favorable metabolic outcome is an important aspect for patients with hypertension and related risk factors.

The practice of microdosing GLP-1 medications has gained attention on social media, driven by patient interest in minimizing common gastrointestinal side effects. However, the concept of **what is considered a microdose of GLP-1** is not standardized, as it involves using amounts significantly lower than standard therapeutic doses prescribed by pharmaceutical manufacturers. This off-label approach aims to balance efficacy with tolerability for individuals seeking a gentler path to metabolic health.

According to a comparative study published in *JAMA Internal Medicine*, individuals with overweight or obesity who were treated with tirzepatide (the active ingredient in Mounjaro) achieved significantly greater weight loss compared to those taking semaglutide (Ozempic/Wegovy). For those seeking an equivalent medication or alternative, the question arises, what drug is most like Mounjaro?

Telmisartan is an angiotensin II receptor blocker (ARB) known for its potent antihypertensive effects, but unlike many other ARBs, it possesses a unique pharmacological profile that offers benefits beyond simple blood pressure control. This includes a notably long half-life and partial agonistic activity on the PPAR-gamma receptor, which provides significant metabolic and cardioprotective advantages.

While carnitine deficiency is a more commonly discussed topic, elevated carnitine levels can also signal underlying metabolic issues. Investigating what causes elevated carnitine is crucial for diagnosing genetic disorders, effects of medication, or conditions like renal disease [1.2.1].

Did you know that the plant-based compound berberine works by activating a metabolic 'master switch' enzyme called AMPK? This mechanism is why some individuals find that taking berberine at night offers targeted benefits for optimizing overnight metabolic health and supporting improved sleep patterns.