Category: Migraine prevention

According to the FDA, Topamax (topiramate) has a mean plasma elimination half-life of approximately 21 hours in adults. Yes, Topamax builds up in your system during the initial phase of treatment until it reaches a stable, therapeutic concentration, a process known as reaching a steady state.

While structurally related to tricyclic antidepressants, the drug pizotifen is not primarily an antidepressant but is most notably characterized as a serotonin and histamine antagonist. It is a unique compound whose class is best defined by its antagonistic actions rather than its structural similarities.