Category: Mycology

Millions of people worldwide are affected by fungal infections, from superficial skin conditions to more serious systemic diseases. For patients and clinicians, balancing effective treatment with minimal side effects is crucial, leading to the common question: **what is the least toxic antifungal**? The answer depends heavily on the infection's location and severity, but certain medications and delivery methods have consistently demonstrated superior safety profiles.

During the Middle Ages, an estimated 50,000 people died from outbreaks of ergot poisoning, known as St. Anthony's Fire, which caused painful convulsions and hallucinations. These deadly episodes raise a critical question for modern pharmacology: **Is ergot a psychedelic drug?** The answer is that while it is mind-altering, it is a poison, not a recreational psychedelic.

According to the CDC, approximately 7% of all *Candida* blood samples tested are resistant to fluconazole, with some emerging species showing even higher resistance rates. Numerous factors can contribute to treatment failure, raising the question: **What makes fluconazole not work?**