Category: Off label uses

First approved for chemotherapy-induced nausea and vomiting in the 1990s, ondansetron's versatile mechanism of action has led to investigations far beyond its original intent, leading many to wonder what else can ondansetron be used for. This broad application, known as off-label use, is based on the drug's effect on serotonin pathways, influencing various bodily functions beyond just the gag reflex.

While primarily known as a pain reliever for moderate to moderately severe pain, the unique dual-action pharmacology of tramadol has led to its exploration for several other medical conditions. These off-label applications raise important questions about **what else can tramadol be used for** and under what circumstances, as they come with distinct benefits and risks.