Category: Opioid addiction

While often marketed as a natural remedy, kratom’s primary alkaloids, mitragynine and 7-hydroxymitragynine, exhibit both partial agonist and antagonist effects across different opioid receptors, making the question, 'Is kratom a partial opioid antagonist?' far more complex than it appears. Its pharmacology is uniquely multifaceted, behaving in some ways like an opioid and in others like a mood-enhancer.

In a 2009 study of German health insurance data, 17.2% of patients treated with tilidine/naloxone showed high usage rates, indicating a potential for dependency [1.2.1]. Understanding **how addictive is Tilidin** involves examining its pharmacology, its formulation with naloxone, and its real-world abuse patterns.

According to the National Institutes of Health, methadone, the active ingredient in Physeptone, is an effective and long-used treatment option for both chronic pain and opioid use disorder. The question, 'What is the drug Physeptone used for?' has two primary answers: managing severe, chronic pain and providing medication-assisted treatment for opioid addiction.

First synthesized in Germany during World War II, methadone—the active ingredient in Metadol D—has served as a powerful synthetic opioid for decades. What is Metadol D used for today is primarily in the treatment of opioid use disorder (OUD) and for managing severe, long-term pain under strict medical supervision.