Category: Pharmaceutical manufacturing

Over 12% of US adults have used a GLP-1 drug, such as semaglutide, highlighting its widespread use. The complex process of how is semaglutide manufactured involves a multi-step journey, combining advanced biotechnology with precise chemical modifications to create a stable and effective therapeutic peptide.

According to the National Institutes of Health, eye drops represent up to 90% of all commercially available ophthalmic drug products, making the methods of preparation of eye drops critically important for patient safety and efficacy. These preparations are complex, sterile formulations designed to deliver medication directly to the surface of the eye while minimizing contamination risks and ensuring patient comfort.

According to pharmaceutical experts, excipients are crucial for creating palatable tablets, and mannitol stands out as the most commonly used base for chewable tablets due to its excellent sensory properties. This article explores the properties of mannitol and compares it with other common excipients used in chewable formulations.

In pharmacology and medicine, the acronym DSP doesn't refer to just one thing, creating confusion for patients and professionals alike. To clarify, this guide explores the primary uses for **what is a DSP used for?** in medication, from Downstream Processing in drug manufacturing to the role of a Direct Support Professional in patient care.

According to Good Manufacturing Practices (GMP), every batch of a drug product must have a comprehensive record. This critical document, known as the **Batch Production and Control Record (BPCR)**, ensures product quality, safety, and regulatory compliance throughout the manufacturing process.

Microcrystalline cellulose (MCC) is arguably the most widely used excipient for solid oral dose formulations, serving as a cornerstone for modern pharmaceutical manufacturing. This versatile material, known by the acronym **MCC in pharmaceutical** production, is essential for its unique binding and compression properties, enabling the creation of robust and stable tablets and capsules.

The use of lyophilization, or freeze-drying, can extend the shelf life of pharmaceuticals, such as vaccines and biologics, for years without refrigeration. A lyophilisate is the solid, porous product resulting from this process, designed to offer superior stability and prolonged shelf life for temperature-sensitive drugs and biologics.

Under Title 21 of the Code of Federal Regulations (CFR), pharmaceutical manufacturers must maintain meticulous records for every drug batch produced [1.3.2, 1.3.3]. Central to this is understanding: **what is BPCR in pharma?** It stands for the Batch Production and Control Record, a cornerstone of quality and regulatory adherence.

Betahistine is a histamine analogue drug prescribed for Meniere's disease in over 80 countries worldwide [1.6.2]. This article provides a high-level scientific overview of the chemical processes explaining how to make betahistine in a regulated laboratory setting.