Category: Pharmaceuticals

Over 90% of drug candidates that enter the clinical trial stage fail to reach the market, highlighting the immense difficulty in getting FDA approval. This staggering statistic underscores the complex and high-risk nature of pharmaceutical research and development, a process fraught with challenges at every turn.

Janssen Pharmaceuticals, a subsidiary of Johnson & Johnson, originally developed and manufactured the brand-name version of topiramate, called Topamax, receiving U.S. Food and Drug Administration (FDA) approval in 1996 for epilepsy. The medication’s initial patent protection eventually expired, paving the way for numerous companies to begin producing generic topiramate.

First approved by the FDA in 2012 for stroke prevention, Eliquis became a blockbuster drug and a central part of a major pharmaceutical collaboration. The partnership responsible for who makes Eliquis medication involves two of the world's largest drug manufacturers, combining their resources to bring the anticoagulant to market.

As of October 2024, Eli Lilly is the most valuable drug company in the world with a market capitalization of $842 billion. This article explores the question: What is Eli Lilly known for, from its foundational role in medicine to its current market dominance?

According to a 2020 study, 108 branded drugs approved between 1983 and 2017 in the U.S. had multiple orphan indications, demonstrating that a drug can have multiple orphan drug designations. This practice of pursuing multiple indications for the same drug has significant implications for patients, pharmaceutical companies, and the broader healthcare system.

According to research, many medications are formulated as hydrochloride salts to enhance their stability and solubility. The question, 'Is hydrochloride the same as promethazine?', stems from a common confusion regarding active pharmaceutical ingredients and their chemical formulations.

Over 90% of commercially available ophthalmic medications are delivered through eye drops due to their non-invasive nature and relative ease of use. The standard administration route for eye drops is topical application to the conjunctival sac, the pocket formed by the lower eyelid.

In the United States, patents are expected to protect semaglutide until at least 2031, delaying any true generic availability. This timeline has fueled public discussion around the high costs and the question, **will there be a generic semaglutide**?

In 2018, AstraZeneca agreed to a massive price cut of over 70% for Tagrisso in China to gain a spot on the National Reimbursement Drug List (NRDL). This decision fundamentally changed the answer to the question, how much is Tagrisso 80 mg in China?, making it dramatically more accessible for millions of patients.

For millennia, ancient civilizations used extracts from willow bark for pain relief, but it wasn't until the late 19th century that chemists successfully synthesized a more tolerable derivative. Today, Aspirin is the most well-known drug made from salicylic acid, created through a chemical modification process.