Does Toradol Cause Constipation? What Patients Need to Know

October 9, 2025 •

4 min read

While more commonly associated with GI bleeding and stomach upset, evidence confirms that constipation is a documented side effect of Toradol (ketorolac). This potent NSAID is used for short-term, moderate-to-severe pain, and understanding its full range of effects is crucial for patient safety and comfort.

Quick Summary

Toradol (ketorolac) can potentially cause constipation, although it is a less common gastrointestinal side effect than others. Patients can manage mild cases with dietary changes, hydration, and exercise.

Key Points

Constipation is a possible side effect: Toradol (ketorolac), an NSAID, can cause constipation, although other GI issues like diarrhea and nausea are more commonly reported.
Toradol's GI effects are dose-dependent: The risk and severity of gastrointestinal side effects, including constipation, increase with higher doses or longer treatment periods.
Toradol is for short-term use only: Due to the potential for serious GI bleeding and other adverse effects, Toradol is prescribed for a maximum of five days.
Lifestyle changes can help: Increasing fluid intake, eating more fiber-rich foods, and staying active are effective strategies for managing mild constipation.
OTC options are available: Bulk-forming laxatives, stool softeners, and osmotic laxatives can provide relief, but should be discussed with a doctor before use.
Seek medical advice for severe symptoms: Severe abdominal pain, bloody stools, or other concerning symptoms require immediate consultation with a healthcare provider.
NSAIDs work differently than opioids: Unlike opioids that directly slow bowel function, Toradol's GI effects are related to its impact on protective prostaglandins in the intestinal lining.

Does Toradol Cause Constipation? The Short Answer

Yes, constipation is a potential side effect of Toradol (ketorolac), though it is not one of the most frequently reported gastrointestinal (GI) issues associated with the drug. Other GI problems like abdominal pain, nausea, and diarrhea are reported more often. However, the risk of developing constipation or other digestive troubles can increase with higher doses or with longer use of the medication. It's crucial for patients to be aware of this possibility, as managing side effects effectively can improve overall comfort during treatment.

Understanding Toradol and Its Mechanism

Toradol, the brand name for ketorolac, is a powerful nonsteroidal anti-inflammatory drug (NSAID) prescribed for the short-term management of moderately severe acute pain. Unlike opioids, which are well-known to cause constipation by directly affecting opioid receptors in the gut, Toradol's mechanism of action and its link to constipation are different.

How NSAIDs like Toradol Work: Toradol works by inhibiting the production of prostaglandins, which are hormone-like substances involved in pain, fever, and inflammation.
Impact on the Gut: Unfortunately, prostaglandins also play a protective role in the stomach and intestinal lining. By blocking these protective prostaglandins, NSAIDs can disrupt the delicate balance of the GI system. This disruption can lead to various symptoms, including constipation, diarrhea, and in more serious cases, ulcers or bleeding.

Gastrointestinal Side Effects of NSAIDs

NSAIDs, as a class of drugs, are known to have a range of GI side effects. This is a primary reason that potent NSAIDs like Toradol are only prescribed for short-term use, typically no longer than five days, to minimize the risk of serious complications.

Here is a list of common gastrointestinal side effects associated with NSAIDs, including Toradol:

Nausea
Stomach pain or discomfort
Indigestion or heartburn
Gas or bloating
Diarrhea
Constipation
Ulcers or gastrointestinal bleeding (a more serious risk)

Managing and Preventing Constipation from Toradol

For those experiencing constipation while taking Toradol, several strategies can help manage the symptoms. It is always important to consult a healthcare provider before starting any new treatment for constipation.

Lifestyle and Dietary Adjustments

Increase Fluid Intake: Drinking plenty of water helps soften stools, making them easier to pass. Staying well-hydrated is a simple yet effective first step.
Eat Fiber-Rich Foods: Incorporating fruits, vegetables, beans, and whole grains into your diet can add bulk to your stool. Good examples include berries, broccoli, lentils, and oatmeal.
Stay Active: Gentle physical activity, like walking, can help stimulate intestinal movement and improve bowel function.

Over-the-Counter Options

Bulk-forming Laxatives: Products like psyllium fiber (Metamucil) or methylcellulose (Citrucel) can add bulk and consistency to stool.
Stool Softeners: Docusate sodium (Colace) works by adding moisture to the stool, preventing straining.
Osmotic Laxatives: Polyethylene glycol (MiraLAX) or magnesium hydroxide (Milk of Magnesia) draw water into the colon to promote a bowel movement.

Note: It's important to use these products as directed and with the guidance of a healthcare professional. Avoid taking multiple types of laxatives together unless specifically instructed to do so.

Comparison of Pain Medications and Constipation

This table provides a general comparison of the likelihood of constipation and other GI side effects for different types of pain medications. It is important to note that individual reactions can vary significantly.


Medication Type	Risk of Constipation	General GI Side Effects	Usage Notes
Toradol (Ketorolac)	Possible (less common than other GI issues)	Abdominal pain, nausea, indigestion, diarrhea	Short-term use (≤ 5 days) due to risk of serious GI bleeding
Opioids (e.g., Morphine, Oxycodone)	High	Nausea, bloating, cramps	Strong link to slowing intestinal movement; requires specific management strategies
Ibuprofen (Advil, Motrin)	Possible	Stomach pain, nausea, heartburn, bloating	OTC option, but carries similar NSAID GI risks, especially with high doses or long use
Acetaminophen (Tylenol)	Low (but possible)	Generally well-tolerated; low GI risk compared to NSAIDs	Does not treat inflammation; safe for kidneys if used as directed but can cause liver damage with overdose

When to Contact a Healthcare Provider

While mild constipation from Toradol is usually manageable, there are situations where you should seek medical advice.

Persistent or Severe Constipation: If constipation does not improve with simple lifestyle changes.
Severe Stomach Pain or Bloody Stools: These could be signs of a more serious problem, such as GI bleeding or ulcers. Look for black, tarry stools or vomit that looks like coffee grounds.
Signs of Allergic Reaction: Difficulty breathing, swelling of the face or throat, and rash require immediate medical attention.
Any Unusual Symptoms: If you experience any symptoms that concern you, contact your doctor for advice.

Conclusion

While not the most common side effect, constipation can occur with the use of Toradol (ketorolac), consistent with its nature as an NSAID. The risk of developing GI issues increases with the dose and duration of treatment, which is why Toradol is limited to a maximum of five days. For mild cases, simple interventions like increasing fluid intake and dietary fiber, along with gentle exercise, can help. Over-the-counter products like bulk-forming laxatives or stool softeners may also be effective, but should be used with medical supervision. Being proactive and informed about Toradol's side effects can help ensure a more comfortable and safe pain management experience.

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Consult a healthcare professional for diagnosis and treatment.

Frequently Asked Questions

Constipation is a listed side effect of Toradol (ketorolac), but it is less common than other gastrointestinal issues like nausea, abdominal pain, and diarrhea.

Toradol, like other NSAIDs, works by inhibiting prostaglandins, which are protective of the intestinal lining. This disruption can cause various GI side effects, including constipation, though the exact mechanism for constipation specifically is not as pronounced as it is with opioids.

To help prevent constipation, you can increase your intake of water and fiber, and stay physically active. If you know you are prone to constipation, discussing preventive measures with your healthcare provider is recommended.

Constipation caused by Toradol is typically temporary and should resolve after you stop taking the medication. Toradol is only meant for short-term use (up to five days), so the side effect duration is also limited.

Over-the-counter options include bulk-forming laxatives (e.g., Metamucil), stool softeners (e.g., Colace), and osmotic laxatives (e.g., MiraLAX). Always consult your doctor before taking new medication for constipation.

You should not take Toradol with other NSAIDs or aspirin, and you must consult your doctor before combining it with other medicines, including those for constipation. Some laxatives may have negative interactions.

Contact your doctor immediately if you experience severe abdominal pain, black or tarry stools, vomit that looks like coffee grounds, or any signs of bleeding or ulceration. While constipation is less severe, persistent or worsening symptoms should also be discussed with a healthcare provider.