How do I use Ryaltris? A comprehensive guide for proper administration

October 7, 2025 •

3 min read

According to the manufacturer, Ryaltris can start providing relief from symptoms of seasonal allergic rhinitis within 15 minutes of the first dose. For this prescription nasal spray to work effectively and safely, it is essential to understand exactly how do I use Ryaltris, from priming the bottle to daily application.

Quick Summary

A step-by-step guide covering the preparation, application, cleaning, and storage of Ryaltris nasal spray for the treatment of allergic rhinitis, outlining the correct priming process.

Key Points

Always prime the bottle: For first-time use, spray six times into the air. If not used for 14 or more days, re-prime with two sprays.
Shake well before each use: Ensure the ingredients are properly mixed by shaking the bottle before every application.
Tilt your head forward: Point the nozzle toward the outside wall of your nostril to avoid spraying the nasal septum and causing irritation or nosebleeds.
Breathe in gently: Inhale slowly through your nose as you spray to draw the medication into the nasal passages, then exhale through your mouth.
Clean the nozzle after every use: Wipe the spray tip with a dry tissue and replace the cap to prevent clogging.
Never use a pin to unblock the nozzle: If the tip is clogged, soak it in warm water for 15 minutes, then rinse and dry before re-priming.
Follow your prescription: Apply Ryaltris as directed by your healthcare provider, including the number of sprays and frequency of use.

Understanding Ryaltris and its purpose

Ryaltris is a prescription nasal spray approved for individuals aged 12 and above to treat seasonal allergic rhinitis. It is a combination medication containing two active ingredients to address allergy symptoms:

Olopatadine: An antihistamine that helps prevent symptoms like itching, sneezing, and runny nose.
Mometasone furoate: A corticosteroid that reduces inflammation in the nasal passages caused by allergies.

This combination targets both immediate allergic reactions and inflammation, providing relief for both nasal and eye symptoms associated with allergic rhinitis.

The importance of proper technique

Using Ryaltris correctly is crucial for its effectiveness and to minimize potential side effects. Improper use, such as spraying directly onto the nasal septum, can lead to issues like nosebleeds. Tilting your head back may cause the medication to go down your throat, resulting in an unpleasant taste and reduced efficacy. By following the proper steps, you can ensure the medication is delivered to the correct area in your nose for optimal results.

Priming your Ryaltris nasal spray

Priming prepares the nasal spray pump for use, ensuring consistent and accurate delivery with each spray.

Initial priming: Before the first use, remove the purple cap, hold the bottle upright and away from your face, and press the pump six times until a fine mist is released.

Re-priming: If the spray hasn't been used for 14 days or more, shake the bottle and press the pump twice until a fine mist appears.

Step-by-step application instructions

For each application, follow these steps:

Gently clear your nostrils by blowing your nose.
Shake the bottle well before each use.
Tilt your head slightly forward and hold the bottle upright.
Close one nostril with your finger. Insert the tip into the other nostril, aiming it towards the outer wall of your nose, away from the center.
Press the pump while gently breathing in through your nose. Breathe out through your mouth. Repeat the action in the same nostril according to your prescription.
Repeat the process for the other nostril, following your prescription.
To allow the medication to absorb, avoid blowing your nose for at least 15 minutes after use.
Wipe the spray tip with a clean, dry tissue and replace the cap.

Proper care and maintenance

Maintaining your Ryaltris nasal spray properly helps prevent blockages and ensures consistent performance.

Daily cleaning: After each use, wipe the nozzle with a clean, dry tissue.
Unblocking: If the nozzle becomes blocked, do not use sharp objects to clear it. Instead, remove the nozzle, soak it in warm water for 15 minutes, rinse, and let it dry completely before reattaching and re-priming with two sprays.
Storage: Store the bottle upright with the cap on at room temperature (68°F to 77°F). Do not freeze or refrigerate.
Disposal: The bottle provides a specific number of sprays after initial priming. Keep track of usage and discard after all usable sprays are depleted.

Ryaltris vs. Other Nasal Sprays

Ryaltris's combination of an antihistamine and a corticosteroid provides a dual action. Here's how it compares to some other nasal sprays:


Feature	Ryaltris	Flonase (Fluticasone)	Dymista (Azelastine/Fluticasone)
Active Ingredients	Olopatadine (Antihistamine) and Mometasone (Corticosteroid)	Fluticasone (Corticosteroid)	Azelastine (Antihistamine) and Fluticasone (Corticosteroid)
Mechanism of Action	Dual-action: blocks histamine and reduces inflammation	Single-action: reduces inflammation only	Dual-action: blocks histamine and reduces inflammation
Onset of Action	Within 15 minutes	May take longer to feel full effect	Fast-acting, similar to Ryaltris
Availability	Prescription only	Over-the-counter (OTC)	Prescription only
Age Range	12 years and older	Varies by formulation; some for children as young as 2	Typically 6 years and older

What to do if you miss an application

If you forget to apply Ryaltris as prescribed, do so as soon as you remember. However, if it is almost time for your next scheduled application, skip the missed one and continue with your regular schedule. Do not use extra sprays to compensate for a missed application, as this could increase the risk of side effects.

Conclusion: Maximizing your allergy relief

Effective use of Ryaltris involves proper priming, application technique, and maintenance. By following the detailed instructions for use and care, you can ensure the medication is delivered correctly, potentially minimizing side effects like nosebleeds. Consistent and proper use of Ryaltris, as directed by your healthcare provider, helps maximize relief from allergic rhinitis symptoms. Always consult your healthcare provider regarding your treatment plan and any concerns you may have.

For more detailed information, you can visit the official Ryaltris website.

Frequently Asked Questions

Ryaltris should be used according to the instructions provided by your healthcare provider.

If you miss a dose, use it as soon as you remember. However, if it is almost time for your next dose, skip the missed one and continue with your regular schedule. Do not double the dose.

To prime for the first time, remove the dust cap, shake the bottle well, and press the pump six times into the air until a fine mist appears.

Tilt your head slightly forward, insert the nozzle into your nostril, and aim the spray toward the outer wall of your nose (away from the center) while breathing in gently. Then, exhale through your mouth.

After each use, wipe the nozzle with a clean, dry tissue. If it becomes blocked, remove the nozzle and soak it in warm water for 15 minutes before rinsing, drying, and re-priming.

Using nasal sprays incorrectly can sometimes cause nosebleeds. If you experience frequent or severe nosebleeds, stop using the medication and report it to your doctor or care team as soon as possible.

Each bottle of Ryaltris contains a specific number of metered sprays after the initial priming. It is recommended to keep track of your usage and discard the bottle after this number of sprays has been administered, as the delivery may become unreliable.