The Dual-Action Formulation of Uniroid
Uniroid's efficacy stems from its two key active components: hydrocortisone and cinchocaine hydrochloride. These ingredients belong to different pharmacological classes, each addressing a distinct aspect of haemorrhoid symptoms. Hydrocortisone, a corticosteroid, is the anti-inflammatory component, while cinchocaine hydrochloride serves as the local anaesthetic to numb the affected area. This combination allows Uniroid to provide both immediate pain relief and to target the underlying inflammation, offering comprehensive symptom management for both internal and external haemorrhoids.
The Science Behind Hydrocortisone's Action
Hydrocortisone is a potent corticosteroid that works by calming the immune system in the local area of application. Inflammation is a complex immune response where the body releases various chemicals, causing blood vessels to dilate and leading to swelling, redness, pain, and itching. The mechanism of action for hydrocortisone involves several steps at the cellular level:
- Binding to glucocorticoid receptors: Once absorbed by the cells in the affected tissue, hydrocortisone binds to glucocorticoid receptors in the cytoplasm.
- Gene modulation: This binding and activation process alters gene expression. The activated receptors enter the cell's nucleus and upregulate anti-inflammatory genes while inhibiting pro-inflammatory genes.
- Inhibition of key enzymes: It also inhibits the production of inflammatory mediators, such as phospholipase A2. By blocking this enzyme, hydrocortisone prevents the formation of prostaglandins and leukotrienes, which are major drivers of the inflammatory response.
By suppressing these inflammatory pathways, hydrocortisone effectively reduces the swelling and irritation associated with haemorrhoids. Its effect is not immediate but builds up over the course of treatment, providing sustained relief from inflammation.
How Cinchocaine Provides Rapid Pain Relief
Cinchocaine hydrochloride is a topical anaesthetic of the amide type, known for its ability to provide rapid and long-lasting pain relief. It works by blocking nerve impulses in the sensory nerve endings in the skin and mucosa. The pharmacological process is as follows:
- Blocking sodium channels: Cinchocaine prevents the initiation and conduction of nerve impulses by blocking the sodium channels within the neuronal membrane.
- Inhibiting depolarization: By preventing the influx of sodium ions, cinchocaine inhibits the depolarisation of the nerve membrane, effectively stopping pain signals from being transmitted along the nerve fibres to the brain.
- Creating a numbing sensation: This blockade of nerve signals results in a local numbing effect, providing immediate and significant relief from the pain and itching caused by haemorrhoids.
This immediate anaesthetic action provides comfort from the most distressing symptoms, making the discomfort of haemorrhoids much more manageable while the hydrocortisone works to reduce the underlying inflammation.
Uniroid's Mechanism in Treating Hemorrhoids
The true power of Uniroid lies in its synergistic action. The cinchocaine provides a fast-acting, soothing sensation that brings immediate comfort, allowing the patient to go about their day with less pain and itching. In parallel, the hydrocortisone is gradually reducing the swelling and inflammation of the haemorrhoidal tissue. This two-pronged attack notmbhhnmnnnot only relieves symptoms but also helps to manage the underlying cause of the discomfort. It is this combined approach that makes Uniroid a highly effective prescription treatment for haemorrhoids.
Forms of Uniroid: Ointment vs. Suppository
Uniroid is available in two main formats to suit different needs and types of haemorrhoids. The choice often depends on the location of the piles and patient preference.
| Feature | Uniroid Ointment | Uniroid Suppository |
|---|---|---|
| Primary Use | External haemorrhoids, can also be used for internal piles. | Internal haemorrhoids only. |
| Application Method | Applied externally with a finger. Comes with a nozzle for internal application. | Inserted directly into the anus to target internal tissue. |
| Mechanism of Action | Combines anaesthetic and anti-inflammatory action for surface and internal relief. | Releases anaesthetic and anti-inflammatory agents directly to internal haemorrhoids. |
| Base Material | A smooth, translucent ointment (white soft paraffin base). | Solid, off-white suppository with a hard fat base. |
Proper Application and Use
Regardless of the format, proper application is crucial for Uniroid's effectiveness and to minimise side effects. A standard course of treatment is typically limited to seven days unless a doctor advises otherwise. The frequency of use is often recommended multiple times daily, including after bowel movements.
For the ointment, a small amount is gently spread over the affected external area. For internal application, the provided nozzle is attached and used as directed. Suppositories should be inserted as far as possible into the rectum after removing the foil wrapping. Hands and applicators must be washed thoroughly before and after use.
Important Safety Information and Precautions
As with any medication, it is essential to follow the usage instructions precisely. Prolonged or excessive use of Uniroid, especially the hydrocortisone component, can lead to side effects. For instance, long-term application can cause thinning or damage to the skin in the treated area. In rare cases with large amounts or regular use, there is a risk of systemic absorption of the corticosteroid, which can affect the adrenal glands.
When to Avoid Uniroid
Uniroid should not be used in certain situations due to potential risks. Contraindications include:
- Allergies to hydrocortisone, cinchocaine, or other ingredients in the product.
- Any form of skin infection in the rectal area, including bacterial or fungal infections like thrush, and viral infections such as herpes, varicella, or vaccinia.
- Tuberculosis.
- Being under 12 years of age, unless explicitly directed by a doctor.
Pregnant or breastfeeding women should also consult a doctor before use, as topical corticosteroids may pose risks. If a patient experiences blurred vision, visual disturbances, or an allergic reaction, they should contact their doctor. For a full list of precautions and side effects, patients should consult the patient information leaflet provided with their medication or refer to authoritative sources like the electronic medicines compendium (eMC).
Conclusion
Uniroid works by combining the fast-acting numbing effect of cinchocaine with the longer-term anti-inflammatory action of hydrocortisone. This dual-action approach provides effective relief from the pain, itching, and swelling associated with haemorrhoids. Its availability in both ointment and suppository forms allows for targeted treatment of both internal and external piles. While offering significant symptomatic relief, it is a short-term, prescription-only medication that requires careful use and adherence to a doctor's instructions to ensure safety and prevent complications.
