How much does Beriplex cost? Understanding the pricing and influencing factors

October 18, 2025 •

4 min read

The average dose of prothrombin complex concentrate (PCC), which includes drugs like Beriplex, can cost thousands of dollars, though the amount a patient pays varies greatly. To answer the question, "How much does Beriplex cost?", one must consider a variety of elements, including geographic location, insurance coverage, and administration costs.

Quick Summary

The cost of Beriplex (or its US equivalent, Kcentra) is not a fixed price and depends on location, insurance plan details, and the total dose required for treatment. Patient expenses can be substantial, but manufacturer assistance programs may offer aid. Other reversal agents, like Andexanet, can be significantly more expensive.

Key Points

Location Matters: The cost of Beriplex (or Kcentra in the US) is heavily dependent on the country and local healthcare system, with NHS prices differing from US estimates.
Insurance is a Major Factor: Patient out-of-pocket costs are determined by insurance coverage, deductibles, and whether the hospital is in-network.
Hospital Costs Add Up: The total bill includes not just the drug price but also costs associated with administration, staff time, and hospital overhead.
Dosage Affects Final Price: The amount of Beriplex needed is based on patient weight and INR, meaning a single treatment is priced based on the total number of vials used.
Alternatives Can Be More Expensive: Compared to newer reversal agents like Andexanet, PCCs are generally more cost-effective, though treatment decisions should prioritize clinical needs.
Assistance Programs are Available: Financial aid may be available through manufacturer patient assistance programs to help mitigate the high cost of treatment.

What is Beriplex and Kcentra?

Beriplex P/N is a four-factor Prothrombin Complex Concentrate (PCC) manufactured by CSL Behring. It is used to rapidly reverse the effects of vitamin K antagonist (VKA) anticoagulation therapy, such as warfarin, in patients experiencing acute major bleeding or requiring urgent surgery. A key point for US patients and healthcare providers is that the same product is marketed under the brand name Kcentra in the United States. While the name changes, the underlying medication and function are consistent. This means that a cost analysis must consider both product names, depending on the patient's location.

PCCs work by providing the necessary coagulation factors (II, VII, IX, and X) to restore the blood's clotting ability. Due to its emergency use, the cost is typically managed within a hospital setting, influencing the final charges seen by the patient.

Key Factors Influencing Beriplex Cost

The final cost of Beriplex or Kcentra is not uniform. Several variables contribute to the ultimate price, including:

Geographic Location: Drug prices are heavily regulated and negotiated by national and regional health systems. An NHS maximum price for Beriplex in the UK, for instance, is listed as significantly different from cost estimates for PCC doses in the US.
Insurance Coverage and Patient Status: As with most medications, a patient's out-of-pocket expense for Beriplex or Kcentra will depend on their specific insurance plan. Factors like copayments, deductibles, and whether the hospital is in-network all play a role. Patients without insurance will face the highest costs.
Hospital and Administration Costs: The total cost includes more than just the drug itself. The price is influenced by the hospital's acquisition cost, as well as associated administrative costs for preparation, nurse time, clinic space, and transport of the medication.
Total Dosage Required: The dose of Beriplex or Kcentra is based on the patient's weight and International Normalized Ratio (INR). A larger dose means a higher drug cost. The total cost is based on the number of vials needed for a complete treatment.

Approximate Cost Ranges for PCC

It is challenging to provide a single price for Beriplex due to the factors above, but data and studies provide valuable cost estimates:

United States: Estimates for a dose of PCC (e.g., Kcentra) can range widely, with one study citing approximately US$3,200 while another mentioned a higher figure of $11,650. US Medicaid data from mid-2024 lists the Wholesale Acquisition Cost (WAC) for Kcentra at $2.98000 (unit unspecified), while the Average Acquisition Cost (AAC) is $1.53146. These figures represent institutional costs and do not reflect patient out-of-pocket expenses.
United Kingdom: An official price list from CSL Behring for the UK indicates a maximum NHS price for Beriplex P/N 1000 IU of £600.00. A different source suggests a cost per vial of £127.50.

Strategies to manage high treatment costs

For patients facing high costs, several strategies can help:

Patient Assistance Programs: Manufacturers like CSL Behring often have programs to provide financial assistance to eligible patients. These can significantly reduce out-of-pocket expenses.
Insurance Optimization: Understanding your specific insurance plan and maximizing your coverage can save substantial amounts, especially for rare and expensive treatments like PCC. Resources from organizations like the National Bleeding Disorders Foundation can be very helpful.
Discussion with Medical Team: Patients should talk openly with their healthcare team about costs and any available lower-cost alternatives or options.

A Cost Comparison of Reversal Agents

For context, it is helpful to compare the cost of PCC (Beriplex/Kcentra) with other reversal agents. A study comparing Andexanet alfa with PCC for reversing direct factor Xa inhibitors (dFXaI) found significant cost differences, based on projected costs.


Reversal Agent	Projected Median Cost per Patient	Hemostasis Rate (Excellent/Good)	Thrombotic Events Rate
PCC (e.g., Beriplex/Kcentra)	$5,670	72% (post-4F-PCC)	4%
Andexanet alfa	$22,120	82% (in trials)	10%

This comparison highlights that while expensive, Beriplex/Kcentra may offer a significantly more cost-effective option compared to newer alternatives like Andexanet alfa for certain uses, though efficacy and risk profiles differ. The higher cost of Andexanet is particularly impactful, with one study noting its cost alone could exceed the entire hospital reimbursement in many cases. For more detailed information on specific patient programs, the National Bleeding Disorders Foundation offers a comprehensive list of resources.

Conclusion on Beriplex Pricing

The cost of Beriplex is variable and influenced by multiple factors, including geography, insurance coverage, and the required dosage. While the drug itself is expensive, especially in a hospital setting where it is administered, several strategies can help manage the financial burden. For US patients, Kcentra is the equivalent product. Comparative studies indicate that PCCs like Beriplex or Kcentra can be significantly less expensive than other reversal agents like Andexanet, although treatment efficacy and safety profile should always be the primary consideration. Ultimately, the best way to determine the cost is to consult with a healthcare provider and insurance company to understand specific out-of-pocket expenses.

Frequently Asked Questions

Beriplex and Kcentra are both brand names for the same four-factor Prothrombin Complex Concentrate (PCC) manufactured by CSL Behring. Beriplex is licensed in Europe, while Kcentra is the brand name used in the United States and other regions.

The final cost is influenced by the patient's geographic location, their specific insurance coverage (including deductibles and copayments), the total dose of the medication required for their treatment, and the associated hospital and administrative fees.

Yes, manufacturers like CSL Behring often offer patient assistance programs to help reduce or cover the out-of-pocket costs for eligible patients. Other organizations, like the National Bleeding Disorders Foundation, also provide resources for managing costs.

Studies show a wide range for the cost of a PCC dose in the US, with estimates ranging from approximately $3,200 to over $11,000. These figures represent overall costs and may not reflect what an insured patient pays out-of-pocket.

Not necessarily. While costly, studies have shown that PCCs like Beriplex can be significantly more cost-effective than newer reversal agents, such as Andexanet, which one study projected to be over four times more expensive.

The variation in price is due to differences in health systems and regulations across countries, varying hospital acquisition costs, and the specific terms of a patient's insurance plan, which can all affect the final price.

The most accurate cost for your specific treatment can only be determined by speaking with your healthcare provider and your insurance company. They can provide an estimate based on your diagnosis, the required dosage, and your plan's coverage.