What is Syndros (dronabinol)?
Syndros is a prescription medication containing dronabinol, a synthetic form of delta-9-tetrahydrocannabinol (THC), which is an active component of cannabis [1.5.2, 1.5.6]. It is the first and only FDA-approved liquid cannabinoid [1.5.1]. Syndros is classified as a Schedule II controlled substance due to its potential for abuse [1.5.2].
This medication is primarily used in adults for two specific conditions [1.5.1, 1.5.5]:
- Chemotherapy-Induced Nausea and Vomiting (CINV): It is prescribed for patients who have not responded adequately to conventional antiemetic (anti-nausea) treatments [1.5.1].
- Anorexia in AIDS Patients: It is used to treat loss of appetite (anorexia) associated with weight loss in individuals with Acquired Immune Deficiency Syndrome (AIDS) [1.5.1].
Because it is a liquid, Syndros may be an option for patients who have difficulty swallowing pills or require medication administered through an enteral feeding tube [1.5.1].
Factors Influencing the Cost of Syndros
The price patients pay for Syndros can vary dramatically based on several key factors. The average retail price for a 30ml, 5mg/ml bottle is often quoted between $5,300 and $5,600 [1.2.1, 1.2.6, 1.3.3]. However, discount programs can lower this price to under $4,800 [1.2.1, 1.3.4].
Key pricing factors include:
- Insurance Coverage: Whether a patient's insurance plan covers Syndros is the most significant variable. Many Medicare Part D plans do not cover the drug, though some may [1.9.1, 1.9.3]. Commercial insurance plans have varying formularies [1.2.6].
- Pharmacy: Prices can differ from one pharmacy to another. Using pharmacy discount cards or comparing prices at different locations can lead to savings [1.3.5].
- Dosage and Quantity: While the standard is a 30ml bottle, the prescribed dosage will determine how long a bottle lasts, affecting the overall monthly cost [1.3.2].
- Patient Assistance Programs: The manufacturer, Benuvia Therapeutics, offers the SYNDROS CARES® program, which can significantly reduce costs for eligible patients [1.4.1, 1.4.2].
Insurance and Medicare Coverage
Navigating insurance coverage for Syndros can be complex. While the federal government classifies cannabis as a Schedule I substance, Syndros, being an FDA-approved synthetic cannabinoid, falls into a different category [1.9.2, 1.9.3].
- Commercial Insurance: Coverage varies by plan. Some plans may require prior authorization or step therapy, where a patient must first try a less expensive alternative, like generic dronabinol capsules, before the plan will cover Syndros [1.9.4]. For commercially insured patients, the SYNDROS CARES® program may lower the co-pay to as little as $0 [1.4.2].
- Medicare: In general, Medicare Part D plans do not cover Syndros [1.9.1]. However, because it is an FDA-approved cannabinoid-based medication, some Medicare Advantage or Part D plans might offer coverage [1.9.2, 1.9.3]. Patients should check their specific plan's formulary. If covered, out-of-pocket costs will depend on the coverage stage (deductible, initial coverage, donut hole) [1.9.1].
- Medicaid: The SYNDROS CARES® program is not valid for patients covered by Medicaid [1.4.2]. Coverage under state Medicaid programs varies.
The SYNDROS CARES® Patient Assistance Program
To help manage the high cost, Benuvia Therapeutics provides the SYNDROS CARES® program. This program offers several benefits [1.4.1, 1.4.2, 1.4.5]:
- $0 Co-Pay for Commercial Insurance: Eligible patients with commercial insurance can pay as little as $0 for their prescription.
- Cash-Pay Discount: For patients paying out-of-pocket, the program offers a discount of up to $400 per bottle.
- Free Trial Voucher: A program for new patients may provide the first 30ml bottle at no cost, regardless of insurance status [1.4.3].
Syndros vs. Generic Dronabinol (Marinol)
Syndros is a brand-name liquid formulation of dronabinol. An alternative is Marinol, which is dronabinol in capsule form, and it also has generic versions available [1.7.2, 1.8.5]. There is a significant price difference between these options.
| Feature | Syndros | Generic Dronabinol (Capsules) |
|---|---|---|
| Formulation | Liquid Oral Solution [1.5.2] | Gelatin Capsule [1.7.2] |
| Active Ingredient | Dronabinol [1.5.2] | Dronabinol [1.7.2] |
| Average Retail Cost | ~$5,400 per 30ml bottle [1.2.6] | ~$83 for 60 capsules (2.5mg) [1.7.2] |
| Administration | Oral syringe [1.5.1] | Swallowed whole |
| Generic Available | No [1.2.6] | Yes [1.7.2] |
While the cost of Syndros is substantially higher, its liquid form offers a necessary alternative for patients who cannot swallow capsules [1.5.1]. Insurance plans may require patients to try the more affordable generic capsules before approving coverage for Syndros [1.9.4].
Potential Side Effects
Like all medications, Syndros can cause side effects. The most common ones involve the central nervous system [1.5.4].
Common Side Effects:
- Feeling "high," euphoria, or heightened awareness [1.6.3, 1.6.4]
- Dizziness, drowsiness, or confusion [1.6.1]
- Nausea, vomiting, or abdominal pain [1.6.1]
- Clumsiness or unsteadiness [1.6.1]
Serious Side Effects:
- Changes in mood, behavior, or worsening of psychiatric symptoms [1.6.3]
- Fast or pounding heartbeat [1.6.3]
- Seizures [1.6.3]
- Low or high blood pressure [1.6.4]
Patients should not drink alcohol or operate heavy machinery while taking Syndros [1.6.3]. It's crucial to discuss your full medical history and all current medications with your doctor before starting treatment [1.6.1].
Conclusion
Answering "how much does Syndros cost?" reveals a complex pricing structure. While the retail price is high, exceeding several thousand dollars per bottle, the final cost to the patient is highly dependent on their insurance plan and eligibility for assistance programs [1.2.1, 1.2.6]. The SYNDROS CARES® program is a critical resource for both commercially insured and cash-paying patients, potentially reducing costs to $0 or providing significant discounts [1.4.2]. Patients considering Syndros should speak with their doctor about its medical necessity and work with their insurer and the manufacturer's assistance program to determine the most affordable path to obtaining this medication. For more information on patient support, visit the official manufacturer's website.
Disclaimer: This article is for informational purposes only and does not constitute medical advice. Consult with a healthcare professional for any medical concerns. You can find more details on patient assistance programs at the SYNDROS CARES® Program website.
