The Core Question: Estrogen in Nexplanon
A direct answer to the question of 'how much estrogen is in the nexplanon?' is zero. Nexplanon is a progestin-only contraceptive method. This distinguishes it from combination hormonal contraceptives like pills, patches, or rings, which contain both estrogen and a progestin.
What Hormone Does Nexplanon Contain?
The Nexplanon implant contains 68 mg of etonogestrel, a synthetic hormone similar to progesterone. This small, flexible rod, about the size of a matchstick, is inserted under the skin of the upper arm. The rod is made of a non-biodegradable plastic (ethylene vinyl acetate copolymer) that allows for slow and consistent hormone release. It also contains barium sulfate for visibility on X-rays.
Hormone Release Rate and Dosage
The 68 mg of etonogestrel is released over a three-year period. The release rate varies:
- Around 60–70 micrograms (mcg) per day initially.
- Decreasing to about 35–45 mcg per day by the end of year 1.
- Around 30–40 mcg per day by the end of year 2.
- Approximately 25–30 mcg per day by the end of year 3. This decreasing dose remains effective for preventing pregnancy for the entire three years.
Mechanism of Action: How Progestin Prevents Pregnancy
Etonogestrel prevents pregnancy in several ways:
- Inhibits Ovulation: Primarily stops the release of an egg from the ovaries.
- Thickens Cervical Mucus: Makes it harder for sperm to reach the uterus.
- Thins Uterine Lining: Alters the endometrium to prevent implantation.
Comparison: Nexplanon vs. Combination Methods
| Feature | Nexplanon (Implant) | Combination Methods (Pill/Patch/Ring) |
|---|---|---|
| Hormone Type | Progestin-only (Etonogestrel) | Estrogen and Progestin |
| Estrogen Content | None | Yes |
| Administration | Subdermal implant in the arm, inserted by a healthcare provider | Daily oral pill, weekly patch, or monthly vaginal ring |
| Duration | Effective for up to 3 years | Requires daily, weekly, or monthly user action |
| Typical Efficacy | >99% effective | Varies by method and user adherence, typically 91-99% |
Why Choose an Estrogen-Free Option?
Avoiding estrogen makes Nexplanon a suitable choice for individuals with specific health concerns. These may include a history of blood clots, stroke, heart attack, certain migraines, high blood pressure, or breast cancer. It is also safe for use while breastfeeding.
Potential Side Effects
Common side effects of Nexplanon include changes in menstrual bleeding patterns, such as irregular bleeding, spotting, or no periods (amenorrhea). Headaches, weight gain, acne, and mood swings have also been reported. Approximately 10% of users discontinue the implant due to bleeding changes.
Conclusion
Nexplanon contains no estrogen; it is a progestin-only contraceptive with 68 mg of etonogestrel released over three years. Its high efficacy and estrogen-free composition make it a valuable long-acting, reversible option, especially for those who need to avoid estrogen. Understanding its hormonal makeup is essential for informed contraceptive choices with a healthcare provider.
For more detailed information, consult the official patient information from the manufacturer, such as this guide from Organon Canada: https://www.organon.com/canada-en/wp-content/uploads/sites/5/2021/05/NEXPLANON-CI_E.pdf.
