Understanding TAKHZYRO Administration
Before administering any medication, it is essential to consult with a healthcare professional. Information provided in this guide is for general knowledge and should not be taken as medical advice.
TAKHZYRO (lanadelumab-flyo) is a subcutaneous injection used to help prevent hereditary angioedema (HAE) attacks. It is provided as a ready-to-use solution in a prefilled syringe. The medication can be self-administered by patients aged 12 and older after they have received appropriate training from a healthcare professional. For children aged 2 to under 12, the injection must be administered by a trained caregiver or healthcare provider. Following the correct procedure is crucial for administering the medication as intended.
Preparing for Your TAKHZYRO Injection
Preparation is a vital first step. Always read the Instructions for Use provided with your medication. Here is a list of what you will need:
- The TAKHZYRO prefilled syringe
- An alcohol swab
- A cotton ball or gauze pad
- An adhesive bandage (optional)
- An FDA-approved sharps disposal container
Before you begin, wash your hands thoroughly with soap and water. Retrieve the prefilled syringe from the refrigerator and allow it to sit at room temperature for at least 15 minutes before injecting. Do not warm the syringe using other methods, and do not shake it vigorously. Inspect the solution in the syringe before use. It should be clear to slightly yellow or opalescent. Do not use the syringe if the liquid is discolored, cloudy, or contains visible particles. If the syringe is cracked or damaged, do not use it and dispose of it properly.
Selecting and Preparing the Injection Site
Choosing the right location for the injection is important. The approved injection sites for TAKHZYRO are:
- Abdomen (at least 2 inches away from the navel)
- Thigh
- Upper arm
To prepare the site, follow these steps:
- Choose a different injection site for each injection. Do not inject into skin that is tender, bruised, scaly, or hard.
- Clean the selected injection site with an alcohol swab and allow it to dry completely. Do not touch, fan, or blow on the cleaned area before injection.
The Subcutaneous Injection Process
Administering the injection involves a few simple, sequential steps. The majority of self-administrations take less than a minute.
- Remove the needle cap: Hold the syringe in one hand and carefully pull the needle cap straight off with the other hand. Avoid twisting. Never put the needle cap back on.
- Pinch the skin: With your free hand, gently pinch a 1-inch fold of skin at the cleaned injection site and hold it throughout the injection.
- Insert the needle: Using a quick, dart-like motion, insert the needle into the pinched skin at a 45- to 90-degree angle. Insert the needle all the way into the fatty layer of the skin.
- Inject the medication: Slowly push the plunger all the way down until it stops. This helps ensure the full dose is administered.
- Remove the needle: Once the plunger is fully depressed, slowly pull the needle straight out while maintaining the same angle.
- Release the skin: Gently release the pinched fold of skin.
After the Injection
Immediately following the injection, it is important to handle the injection site and the used syringe correctly.
- Press a cotton ball or gauze pad over the injection site for about 10 seconds.
- If needed, cover the site with an adhesive bandage.
- Do not rub the injection site, as this can cause bruising or irritation.
- Dispose of the used prefilled syringe immediately into an FDA-approved sharps disposal container. Never reuse the syringe.
TAKHZYRO Administration Comparison by Age Group
TAKHZYRO administration can differ based on the patient's age and who is administering the medication. The following table provides a comparison of these factors.
| Feature | Pediatric Patients (2 to <6 years old) | Pediatric Patients (6 to <12 years old) | Adult and Pediatric Patients (12+ years old) |
|---|---|---|---|
| Who Administers? | Healthcare provider or caregiver | Healthcare provider or caregiver | Patient or caregiver (after training) |
| Supplies Needed | Syringe, alcohol swab, bandage, sharps container | Syringe, alcohol swab, bandage, sharps container | Syringe, alcohol swab, bandage, sharps container |
Important Safety Considerations
While TAKHZYRO is used for many, it is essential to be aware of potential serious side effects, including allergic reactions. Seek immediate medical attention if you or your child experience any of the following symptoms:
- Wheezing or difficulty breathing
- Chest tightness
- Fast heartbeat
- Faintness or dizziness
- Rash or hives
Conclusion
Administering TAKHZYRO is a process that can be performed at home after proper training from a healthcare professional. By following the correct steps for preparation, injection, and post-injection care, patients and caregivers can help ensure the medication is delivered appropriately. Adherence to the prescribed dosing schedule is essential for the management of HAE attacks. Always consult your healthcare provider with any questions or concerns and be vigilant for signs of allergic reactions, seeking immediate medical care if they occur. Proper storage and disposal of the prefilled syringe are also critical components of the administration process.
For more information on TAKHZYRO, including safety and full prescribing information, visit the official Takeda product website at www.takhzyro.com.
