Understanding Tesamorelin (Egrifta SV)
Tesamorelin is a prescription injectable medication sold under brand names like Egrifta SV. It functions by stimulating the pituitary gland to produce and release growth hormone, which in turn helps reduce visceral adipose tissue (VAT), the deep abdominal fat that can accumulate in some individuals with HIV. It is not intended for weight loss management. The currently available 2mg per vial formulation requires a specific reconstitution process before it can be prepared for administration. Following the correct procedure is essential to ensure the medication is effective and to minimize risks like injection site reactions.
Important Safety Information Before You Begin
Before handling Tesamorelin, it is crucial to be aware of several key precautions. This medication is contraindicated in individuals with active malignancy, a history of pituitary tumors or surgery, head trauma, or during pregnancy due to potential fetal harm. It can also increase the risk of glucose intolerance, diabetes, and fluid retention. Side effects may include joint pain, swelling, and redness at the injection site. Always consult with a healthcare provider to ensure Tesamorelin is appropriate for you and to be screened for any underlying conditions. Inform your doctor of all other medications you are taking, as interactions can occur with drugs like corticosteroids and simvastatin.
Step-by-Step Guide: How to Mix 2mg Tesamorelin
The following instructions are specifically for the Egrifta SV 2mg vial formulation. This process is known as reconstitution, where the lyophilized (freeze-dried) powder is mixed with a diluent to prepare it for injection.
1. Gather Your Supplies
You will receive your medication in two boxes: a Medication Box and an Injection Box. Before starting, ensure you have the following items:
- One 2mg vial of Tesamorelin (Egrifta SV) powder.
- One vial of Sterile Water for Injection, USP (the diluent).
- One syringe and needle for reconstitution.
- Alcohol swabs.
- A puncture-resistant sharps container for safe disposal.
Store the unmixed Tesamorelin vials and the diluent at room temperature, between 68°F to 77°F (20°C to 25°C), protected from light.
2. Prepare the Vials
- Wash your hands thoroughly with soap and water.
- Remove the protective caps from both the Tesamorelin vial and the Sterile Water for Injection vial.
- Wipe the rubber stopper on top of each vial with a new alcohol swab.
3. Reconstitution Process
- Draw the Diluent: Using the provided syringe, draw up the required amount of the Sterile Water for Injection, typically 0.5 mL for the 2mg vial. Ensure you measure the volume accurately.
- Inject into Powder: Insert the needle of the syringe into the center of the Tesamorelin vial's rubber stopper. To prevent foaming, angle the needle so the sterile water runs down the inside wall of the vial instead of being sprayed directly onto the powder. Slowly push the plunger to inject all of the water into the vial.
- Mix Gently: Remove the syringe and roll the vial gently between your hands for 30 seconds. Do not shake the vial, as this can damage the medication. Continue rolling until the powder is completely dissolved and the solution is clear and colorless.
- Inspect the Solution: Before drawing the dose, visually inspect the solution. It should be clear, colorless, and free of any particles. If the solution is cloudy, colored, or contains particles, do not use it.
The reconstituted solution contains 2 mg of Tesamorelin in a specific volume of fluid, typically 0.5 mL.
4. Drawing and Administering the Dose
After reconstitution, the solution is prepared for subcutaneous injection (under the skin) into the abdomen. Consult your healthcare provider for the precise volume of the reconstituted solution to draw into a new injection syringe for your prescribed dose.
- Invert the vial and draw the prescribed volume of the mixed solution into a new injection syringe.
- The injection is administered into the abdomen.
- It is crucial to rotate injection sites daily to different areas of the abdomen to reduce the risk of irritation, pain, or bruising. Avoid injecting into the navel, scar tissue, or bruised skin.
- Important: The reconstituted Egrifta SV solution must be used immediately. Do not refrigerate or freeze the mixed solution. Discard any unused portion after drawing your dose.
Drug Formulation Comparison
It is vital not to confuse different formulations of Tesamorelin, as they have different mixing and storage protocols.
| Feature | Egrifta SV (2 mg/vial) | Egrifta WR (11.6 mg/vial) |
|---|---|---|
| Reconstitution Frequency | Daily, before each preparation | Once weekly |
| Diluent Type | Sterile Water for Injection | Bacteriostatic Water for Injection |
| Storage After Mixing | Use immediately, do not store | Can be stored at room temp for up to 7 days |
Conclusion
Properly mixing 2mg Tesamorelin is a straightforward but precise process that is critical for the medication's effectiveness and your safety. Always follow the specific instructions for the Egrifta SV formulation, which involves reconstituting a 2mg vial with sterile water, preparing the required volume for administration immediately, and rotating injection sites. Never shake the vial, and always inspect the solution before use. By adhering to these steps and the guidance of your healthcare provider, you can ensure the safe and proper preparation of Tesamorelin. For more detailed instructions, refer to the patient information provided by the manufacturer.
