Understanding Deflazacort Suspension
Deflazacort is a corticosteroid prodrug used primarily to treat Duchenne muscular dystrophy (DMD), a genetic disorder causing progressive muscle weakness. The oral suspension formulation is often prescribed for children and adults who may have difficulty swallowing tablets. It's crucial to understand that deflazacort is not a cure for DMD but helps to manage symptoms and improve muscle strength. Its anti-inflammatory and immunosuppressive properties play a role in slowing the progression of the disease.
Before You Begin: Essential Preparation
Proper preparation is the first and most critical step in administering deflazacort suspension. Ignoring any of these steps can compromise the dose and its effectiveness. Always consult your pharmacist or healthcare provider if you have any questions.
- Read the instructions for use: Before your first dose, read the patient information and instructions for use provided by the manufacturer and your pharmacist. If the suspension bottle is new, it may require a one-time adapter placement.
- Gather materials: You will need the deflazacort suspension, the special oral dispenser provided with the medication, and a cup with 3 to 4 ounces (90 to 120 mL) of milk or juice.
- Never use grapefruit juice: A critical interaction exists between deflazacort and grapefruit juice. It can significantly increase the medication's effect, leading to a higher risk of side effects. Always use milk or an alternative juice.
- Shake well: Before measuring each dose, shake the bottle thoroughly to ensure the medication is evenly mixed.
- Confirm the dose: Double-check the prescribed dose with your doctor or pharmacist. The appropriate amount is typically determined based on factors like body weight and should be carefully followed.
A Step-by-Step Guide to Administration
Following these steps carefully will ensure the patient receives the correct amount of deflazacort suspension.
- Measure the dose: Insert the provided oral dispenser into the adapter on the bottle top. With the bottle upside down, slowly pull back on the plunger until the prescribed amount is accurately measured. Avoid air bubbles; if they appear, push the plunger back in and re-measure.
- Mix the medication: Carefully transfer the measured dose from the oral dispenser into a cup containing 3 to 4 ounces of milk or juice (not grapefruit juice). Slowly push the plunger down to release the medication.
- Stir thoroughly: Use a spoon to mix the medication and liquid well. The mixture should be administered immediately after mixing.
- Administer immediately: The patient must drink the entire mixture right away. Do not prepare it in advance or save any leftovers for later.
- Rinse and repeat (optional): To ensure the entire amount is received, you can use the same cup and a small amount of additional liquid to rinse the remaining mixture and drink it.
- Clean the dispenser: After each use, wash the oral dispenser thoroughly with water and let it air dry. The bottle cap should be replaced tightly.
Storage and Disposal: Important Instructions
Proper storage and disposal protect the medication's integrity and prevent accidental ingestion.
- Store the bottle upright at room temperature, away from excessive heat or moisture.
- Once opened, discard any unused suspension after one month. It is helpful to write the date of opening on the bottle to track this.
- Dispose of expired or unused medication safely. Your pharmacist can provide guidance on local take-back programs.
Oral Suspension vs. Tablets: A Comparison
| Feature | Deflazacort Oral Suspension | Deflazacort Tablets |
|---|---|---|
| Administration Method | Taken as a mixed liquid, often with milk or juice. | Can be swallowed whole or crushed and mixed with applesauce. |
| Measuring Device | Requires the use of the provided oral dispenser for accurate administration. | Does not require a special dispenser. Different tablet strengths may be combined for the prescribed amount. |
| Formulation for Pediatric Use | Commonly used for children who have difficulty swallowing pills. | May be crushed for easier administration if needed. |
| Preservative | Contains benzyl alcohol, which carries specific risks for infants under 2 years old. | Does not contain benzyl alcohol. |
| Ease of Use | Provides flexibility for those with swallowing difficulties, but requires preparation steps. | Simpler for individuals who can swallow pills without issue. |
Conclusion
Using deflazacort suspension correctly is crucial for patients with Duchenne muscular dystrophy. Accurate administration, careful preparation, and immediate ingestion are key steps in the process. By following the instructions for mixing with milk or juice (avoiding grapefruit juice), using the provided dispenser, and adhering to strict storage guidelines, caregivers and patients can ensure they receive the full therapeutic benefit while minimizing risks. Never stop or adjust the amount without consulting a healthcare provider, as abrupt discontinuation can lead to severe side effects. Ongoing communication with your healthcare team is essential to monitor for both therapeutic response and potential adverse effects. For additional information, consult resources like the FDA-approved prescribing information, which includes detailed patient counseling guidance.
