Constella and Linzess: One Drug, Different Names
Linzess and Constella are brand names for the same medication, linaclotide. Linzess is used in the United States and Mexico, while Constella is marketed in Europe and other areas. The drug's formulation, how it works, and its intended use are the same regardless of the name.
The Common Active Ingredient: Linaclotide
Linaclotide is the active ingredient in both Constella and Linzess. This synthetic peptide works mainly in the gastrointestinal tract with minimal absorption into the bloodstream. It is taken orally to treat certain chronic constipation types.
How Linaclotide Works: Mechanism of Action
Linaclotide is a guanylate cyclase-C (GC-C) agonist. It works as follows:
- It attaches to GC-C receptors on intestinal cells.
- This increases cyclic guanosine monophosphate (cGMP) levels inside and outside the cells.
- Higher intracellular cGMP activates the CFTR ion channel, increasing chloride and bicarbonate secretion into the intestines.
- This fluid influx softens stools and increases bowel movement frequency.
- Increased extracellular cGMP also helps reduce gut pain by affecting pain-sensing nerves, easing discomfort from IBS-C.
Therapeutic Uses: Addressing Chronic GI Conditions
Linzess and Constella are prescribed for adults with two specific conditions:
- Irritable Bowel Syndrome with Constipation (IBS-C): Characterized by chronic abdominal pain and constipation. Linaclotide helps manage both constipation and symptoms like bloating.
- Chronic Idiopathic Constipation (CIC): Long-term constipation without a known cause.
Administration
Linaclotide is typically taken at least 30 minutes before the first meal of the day. It is available in capsule form. The appropriate amount is determined by a healthcare provider based on the individual's needs.
Comparison Table: Constella vs. Linzess
| Feature | Constella | Linzess |
|---|---|---|
| Active Ingredient | Linaclotide | Linaclotide |
| Mechanism of Action | Guanylate Cyclase-C Agonist | Guanylate Cyclase-C Agonist |
| Primary Use | IBS-C and CIC | IBS-C, CIC, and Functional Constipation in pediatric patients 6-17 in US |
| Key Indications | Symptomatic treatment of moderate to severe IBS-C and CIC in adults | Symptomatic treatment of IBS-C and CIC in adults |
| Geographical Market | Europe and other regions | United States, Mexico, and other regions |
| FDA Status | Not applicable (EU approved) | FDA-approved in the US since 2012 |
| Common Side Effects | Diarrhea, abdominal pain, bloating, gas | Diarrhea, abdominal pain, bloating, gas |
Important Safety Information and Side Effects
The most common side effect of linaclotide is diarrhea, which can be severe. Other side effects include abdominal pain, gas, and bloating.
A Boxed Warning in the US cautions against giving linaclotide to children under 2 due to fatal dehydration risk.
Stop taking the medication and contact a doctor if you have severe diarrhea, bloody stools, or signs of dehydration.
Conclusion
Constella and Linzess are the same medication, linaclotide, used for IBS-C and CIC. The only difference is the brand name used in different regions. Both increase intestinal fluid and reduce pain by targeting GC-C receptors. For more information, consult a healthcare provider and see {Link: FDA website https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/202811s021lbl.pdf}.
