Is diclofenac sodium topical gel the same as Voltaren? A Comprehensive Comparison

October 9, 2025 •

4 min read

According to the U.S. Food and Drug Administration (FDA), generic medications must contain the same active ingredient, strength, and dosage form as their brand-name counterparts. This regulatory standard is the core reason diclofenac sodium topical gel is considered equivalent to Voltaren, as they share the exact same active pharmaceutical ingredient, diclofenac sodium.

Quick Summary

This article explores the relationship between Voltaren and generic diclofenac sodium topical gel. Both products use the same active ingredient and offer localized pain and inflammation relief, but differ in cost and inactive ingredients. This guide breaks down the comparison to help you understand the similarities and contrasts.

Key Points

Active Ingredient: Both Voltaren and generic diclofenac sodium gels contain the same active ingredient, diclofenac sodium.
Efficacy: Both versions are required by the FDA to be therapeutically equivalent and provide the same pain-relieving effect.
Cost Difference: Generic diclofenac is typically much more affordable than the brand-name Voltaren.
Inactive Ingredients: While the active ingredient is the same, inactive ingredients, formulation, and consistency may differ between brand and generic versions.
Localized Relief: Topical application of diclofenac delivers the NSAID directly to the site of pain, leading to fewer systemic side effects compared to oral NSAIDs.
Consumer Choice: Deciding between Voltaren and generic diclofenac often depends on balancing cost considerations with personal preference for the formulation's texture and feel.
FDA Approval: Generic diclofenac gels are rigorously reviewed by the FDA to ensure they are as safe and effective as the brand-name product they copy.

The Active Ingredient: Diclofenac Sodium

At the heart of both brand-name Voltaren and its generic versions is diclofenac sodium. This active ingredient belongs to a class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs work by inhibiting the body's production of prostaglandins, which are compounds that play a key role in causing pain and inflammation.

When applied topically, diclofenac sodium is absorbed through the skin and penetrates into the underlying joint tissues, such as the synovium. This localized application allows the medication to treat pain and inflammation directly at the source, offering an advantage over oral NSAIDs by reducing the risk of systemic side effects like stomach upset and cardiovascular events. The FDA approved the 1% diclofenac sodium topical gel for over-the-counter (OTC) use in 2020 for the temporary relief of arthritis pain in certain joints, such as the hands, wrists, elbows, feet, ankles, and knees.

Brand vs. Generic: What Are the Differences?

While the active ingredient is identical, there are several key differences between a brand-name medication like Voltaren and its generic version. These distinctions primarily revolve around cost and the formulation's inactive ingredients. The FDA mandates that generic drugs be bioequivalent to their brand-name counterparts, meaning they have the same strength, dosage form, and therapeutic effect.

Inactive Ingredients and Formulation

One of the most notable differences is the use of inactive ingredients. Voltaren uses a proprietary formula called Emulgel™, which combines a gel and a cream. This specialized vehicle is designed to enhance skin penetration and deliver the diclofenac deep into the tissues. Generic diclofenac gels are not legally permitted to have the same appearance or formulation as the brand name due to trademark laws, so their inactive ingredients may vary. While these variations are not expected to change the medication's effectiveness, they can affect the gel's consistency, scent, or how it feels on the skin.

Cost and Affordability

Perhaps the most significant difference for consumers is the price. Generic drugs are typically much more affordable than brand-name drugs because the manufacturers do not bear the costs of the original research, development, and marketing. Studies show that generics can cost 80% to 85% less than their brand-name counterparts, offering substantial savings for those needing long-term pain management. This cost difference is a major driver for many patients and healthcare providers when choosing a medication.

Efficacy and Safety Profile

Numerous clinical studies have shown that topical diclofenac provides effective relief for the pain and inflammation associated with osteoarthritis, with efficacy comparable to oral NSAIDs. The topical route of administration offers a more favorable safety profile, as it results in significantly lower systemic exposure to diclofenac. This minimizes the risk of gastrointestinal, cardiovascular, and kidney-related side effects that can occur with oral NSAIDs, especially in older patients or those with pre-existing conditions.

Side effects associated with the topical gel are mostly localized to the application site and can include dry skin, redness, itching, or contact dermatitis. These adverse events are typically mild and transient. While the base formulation can differ between brand and generic, the FDA's bioequivalence standards ensure the active ingredient, diclofenac sodium, performs its pain-relieving function equally well in both versions.

How to Choose

Choosing between brand-name Voltaren and a generic diclofenac sodium topical gel depends on a patient's priorities and individual response. Factors to consider include cost, personal preference regarding the feel and scent of the product, and availability. For those looking for the most budget-friendly option without sacrificing the medication's therapeutic effect, a generic is a reliable choice. Patients with a specific sensitivity or preference for the Emulgel™ formulation may opt for Voltaren.

Always consult with a pharmacist or healthcare provider, especially if you have sensitive skin, other medical conditions, or are taking other medications. They can offer guidance based on your individual health needs and help you decide on the best option for your specific situation. The FDA's rigorous approval process provides assurance that both products are safe and effective for their intended use.

Comparison of Diclofenac Gels


Feature	Brand-Name Voltaren	Generic Diclofenac Sodium Topical Gel
Active Ingredient	Diclofenac sodium (1%)	Diclofenac sodium (1%)
Inactive Ingredients	May contain proprietary formulas, such as Emulgel™	Vary by manufacturer, designed to be bioequivalent
Cost	Higher due to branding, marketing, and R&D costs	Typically significantly lower price point
FDA Approval	Approved as a brand-name drug	Approved as a bioequivalent copy of the brand drug
Consistency & Feel	Specific gel-cream blend (Emulgel™)	Can vary; generally similar but not identical
Therapeutic Effect	Identical to the generic due to the same active ingredient	Identical to the brand-name due to the same active ingredient

Conclusion

In conclusion, the core function and primary therapeutic effect of diclofenac sodium topical gel and brand-name Voltaren are identical because they contain the same active ingredient at the same concentration. The main points of divergence are the cost and the specific inactive ingredients that constitute the gel's base formulation. By choosing a generic version, consumers can access the same proven arthritis pain relief for a fraction of the cost, assured by the FDA's strict bioequivalence standards. Ultimately, the choice comes down to weighing the potential cost savings of a generic against any personal preferences for the brand's specific formula.

For more information on the FDA's approval process for generic drugs, visit the official website: www.fda.gov/drugs/generic-drugs/generic-drug-facts.

Frequently Asked Questions

No, generic diclofenac sodium gel is not considered less effective. The FDA requires that all generic medications, including topical gels, must be bioequivalent to their brand-name counterparts, meaning they have the same active ingredient, strength, and therapeutic effect.

Voltaren is a brand-name drug, and its higher cost reflects the original investment in research, development, and marketing by the manufacturer. Generic manufacturers can offer the same medication for less because they do not have to recoup these initial costs.

The main difference is the inactive ingredients used in the formulation base. Voltaren's Emulgel™ is a specific gel-cream mixture designed to enhance skin penetration. Generic versions use different inactive ingredients, but the FDA ensures the final product is bioequivalent in effect.

Yes, you can generally switch between the two with no difference in therapeutic outcome. Both contain the same active ingredient and are approved for the same indications. However, consult a pharmacist if you have concerns about different inactive ingredients or skin sensitivities.

Since both products share the same active ingredient and must meet the same FDA safety standards, they have similar side effect profiles. Most side effects from topical diclofenac are mild and localized, such as skin irritation.

While some people may feel relief within a few days, it can take up to a week of consistent, regular use to feel the full effects of topical diclofenac for arthritis pain.

Generally, yes. Because topical diclofenac has lower systemic absorption, it has a reduced risk of serious side effects associated with oral NSAIDs, such as gastrointestinal bleeding and cardiovascular issues.