Is Hydrocortisone Cream Good for Stings? A Comprehensive Guide

October 14, 2025 •

5 min read

According to Harvard Health, applying over-the-counter hydrocortisone cream is a standard recommendation for relieving the itching and swelling associated with insect stings. As a mild corticosteroid, it effectively calms the localized immune response, which is responsible for the classic symptoms of pain and inflammation.

Quick Summary

Hydrocortisone cream is effective for relieving minor itching and swelling from insect stings and bites. This mild corticosteroid suppresses the inflammatory response to reduce irritation. The article details its proper application, potential side effects, and compares it with other remedies, and advises on when to seek medical attention.

Key Points

Effective for minor stings: Hydrocortisone cream, available in various OTC concentrations, is a mild corticosteroid that effectively relieves minor itching and swelling from insect stings.
Reduces inflammation: It works by suppressing the body's local immune and inflammatory response, which minimizes redness, swelling, and itching.
Proper application is key: After removing any stinger and cleaning the area, apply a thin layer of cream as directed for a limited duration.
Watch for side effects: Avoid long-term use, as it can lead to skin thinning and other issues. Local irritation can also occur.
Alternatives are available: For different needs, alternatives include cold compresses for swelling, oral antihistamines for widespread itching, and calamine lotion for soothing.
Seek emergency help for severe reactions: Immediate medical attention is required for signs of a severe allergic reaction (anaphylaxis), such as difficulty breathing, hives, or swelling of the face.

What is hydrocortisone and how does it work on stings?

Hydrocortisone is a mild corticosteroid, a type of medication that reduces inflammation in the body. When an insect stings, its venom triggers a localized inflammatory and immune response in the skin. This reaction involves the release of chemicals like histamine, which cause the area to become red, swollen, and itchy. Hydrocortisone cream works by suppressing this immune response at the site of the sting, thereby reducing the associated itching, redness, and swelling. It is particularly effective for soothing the discomfort of minor and non-allergic sting reactions. Over-the-counter (OTC) hydrocortisone creams are commonly available in various concentrations.

How to properly apply hydrocortisone cream for a sting

Proper application is crucial for maximizing the benefits of hydrocortisone cream while minimizing potential side effects. Here are the key steps to follow:

Remove the stinger: For bee stings, the stinger often remains in the skin and should be removed immediately. Use a fingernail or the blunt edge of a credit card to scrape it away. Avoid using tweezers, which can squeeze the venom sac and release more venom. Other insects like wasps do not leave a stinger behind.
Clean the area: Wash the sting site gently with soap and water to prevent infection.
Apply a cold compress: Immediately applying a cold pack or ice wrapped in a cloth to the area for 10 to 20 minutes can help reduce pain and swelling by constricting blood vessels.
Apply the cream: Spread a thin, even layer of hydrocortisone cream over the affected skin area. Rub it in gently until it disappears.
Follow usage instructions: Apply the cream as directed by the product packaging or a healthcare professional.
Avoid other creams: Do not apply hydrocortisone cream at the same time as other topical products like moisturizers. Leave at least 10 minutes between applications of different creams.
Do not bandage: Unless directed by a doctor, do not cover the treated area with a bandage or other occlusive dressing, as this can increase the risk of side effects.
Limit use: For insect stings, use hydrocortisone cream for a short duration, as typically indicated for minor skin irritations or as soon as the skin improves. Prolonged use can lead to skin thinning or other complications.

Potential side effects and precautions

While OTC hydrocortisone is generally safe for short-term use, some side effects can occur, especially with overuse or on sensitive skin areas.

Common side effects include:

Burning, stinging, or irritation at the application site.
Redness or dryness of the skin.
Acne-like eruptions.

Serious side effects (often associated with prolonged or high-dose use) can include:

Thinning of the skin, making it fragile and prone to easy bruising.
Changes in skin pigmentation.
Red or purple lines on the skin (stretch marks).

Precautions:

Avoid applying the cream to the face, groin, or underarms unless a doctor advises it.
Do not use on broken or infected skin unless advised by a healthcare provider.
For children, consult a doctor before use, as they may have an increased risk of side effects.
Do not swallow the cream or get it in your eyes or mouth.

Alternatives and combination therapies

Sometimes, other options are better suited for a sting or can be used in combination with hydrocortisone. It's important to choose the right treatment for your specific symptoms.

Cold compress/ice pack: As mentioned, this is an excellent immediate treatment for swelling and pain.
Oral antihistamines: For significant itching, an oral antihistamine like cetirizine (Zyrtec) or loratadine (Claritin) can be very effective by blocking the histamine response from within. These are often recommended alongside topical treatments.
Calamine lotion: This can soothe the skin and help reduce itching from weeping lesions.
Baking soda paste: A paste made from baking soda and water can help neutralize venom and relieve itching.
Aloe vera: The gel from this plant is known for its soothing properties and can provide relief for minor pain and itching.

Comparison Table: Hydrocortisone vs. Other Topical Options


Feature	Hydrocortisone Cream	Topical Antihistamine Cream	Calamine Lotion	Baking Soda Paste
Primary Function	Reduces inflammation, itching, and swelling	Relieves itching by blocking histamine	Soothes skin, reduces itching and irritation	Neutralizes venom, reduces itching
How It Works	Suppresses local immune response (corticosteroid)	Blocks histamine receptors (antihistamine)	Mild astringent, absorbs fluids	Alkaline properties
Duration of Use	Short-term use for stings, as directed; prolonged use not recommended	Short-term use; prolonged use risks contact dermatitis	As needed	Short-term relief
Main Side Effects	Skin thinning, irritation, dryness	Photosensitivity, contact dermatitis	Mild stinging, irritation	Mild irritation or dryness
Who Can Use	Adults and children (consult doctor for children)	Adults (potential for drowsiness)	Safe for most, generally gentle	Safe for most, generally gentle
Best For	Localized redness, swelling, and itchiness	Quick, targeted itch relief	Soothing mild irritation and drying weepy spots	Temporary, on-the-spot itch relief

When to seek medical attention

While most stings can be managed at home, some situations require immediate medical attention. Seek emergency care if you or someone else experiences any of the following symptoms, which may indicate a severe allergic reaction (anaphylaxis):

Respiratory distress: Difficulty breathing, wheezing, or feeling like your throat is closing.
Widespread swelling: Swelling of the lips, tongue, face, or eyes.
Dizziness or loss of consciousness: Feeling lightheaded, dizzy, or fainting.
Hives or rash: Widespread, itchy rash that appears over other parts of the body, not just the sting site.
Gastrointestinal issues: Nausea, vomiting, abdominal pain, or diarrhea.

Contact your doctor if a sting shows signs of infection (worsening redness, warmth, pus, fever) or if symptoms do not improve after a few days of home treatment.

Conclusion

For most minor insect stings, hydrocortisone cream is a good and effective option for relieving the local inflammation, itching, and swelling. It works by suppressing the immune response at the sting site, offering targeted relief when applied correctly for a short duration as indicated. However, it is essential to follow proper application instructions, be aware of potential side effects, and consider other remedies like cold compresses and oral antihistamines. Crucially, if you experience any signs of a severe allergic reaction, such as widespread swelling or difficulty breathing, immediate emergency medical attention is necessary.

Authority Link: For more information on treating insect bites and stings, consult the Mayo Clinic's first aid guide. https://www.mayoclinic.org/first-aid/first-aid-insect-bites/basics/art-20056593

Frequently Asked Questions

Yes, hydrocortisone cream can be used for a bee sting after the stinger has been removed. It will help reduce the localized swelling and itching associated with the venom.

Hydrocortisone cream is a more targeted anti-inflammatory agent, making it generally more effective for reducing the swelling and intense itching of a sting. Calamine lotion is primarily a soothing astringent that helps dry out weepy lesions and relieve minor itching.

Apply hydrocortisone cream to insect stings as directed by the product packaging or a healthcare professional, for a limited duration of use.

Signs of a severe allergic reaction (anaphylaxis) include difficulty breathing, swelling of the face, throat, or tongue, a widespread rash or hives, dizziness, or a rapid heart rate. Call 911 or seek immediate emergency care if these symptoms occur.

While low-strength OTC hydrocortisone is sometimes used, it is best to consult a pediatrician before using it on children, especially young ones. Children are more susceptible to side effects, and overuse can cause problems.

You should not apply hydrocortisone cream to open wounds or broken skin. If a blister has formed, it is better to avoid applying the cream directly to that area and consult a healthcare provider for advice.

The main difference is the base. Ointments are greasier and more effective at driving the medication into the skin, while creams are lighter and are often preferred by patients. For many minor conditions like stings, both are effective, but patient preference and lesion characteristics can guide the choice.