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Is There Codeine in Soma? Understanding Carisoprodol and Its Combinations

3 min read

According to 2023 data from the National Survey on Drug Use and Health, approximately 671,000 people aged 12 or older used Soma [1.11.1]. A common question is, is there codeine in Soma? The answer depends on the specific formulation prescribed.

Quick Summary

Soma's active ingredient is carisoprodol, which is not an opioid. However, a combination version, Soma Compound with Codeine, does contain the opioid codeine phosphate, along with aspirin.

Key Points

  • Soma's Active Ingredient: The primary active ingredient in Soma is carisoprodol, a skeletal muscle relaxant, not an opioid [1.3.2].

  • Combination Formula: A separate product, 'Soma Compound with Codeine', contains carisoprodol, aspirin, and the opioid codeine [1.2.4]. This formulation has been discontinued in the U.S. [1.4.5].

  • Different Drug Classes: Carisoprodol is a muscle relaxant, while codeine is a narcotic (opioid) analgesic; they work through different mechanisms [1.4.1, 1.5.2].

  • Controlled Substances: Carisoprodol is a Schedule IV controlled substance, while the combination product with codeine was a Schedule III substance [1.7.1, 1.6.1].

  • Serious Interaction Risks: Combining carisoprodol with codeine or other CNS depressants (like alcohol or benzodiazepines) is dangerous and can lead to severe sedation, respiratory depression, and death [1.6.2, 1.6.4].

In This Article

Understanding Soma (Carisoprodol)

Soma is the brand name for the drug carisoprodol, which belongs to a class of medications known as skeletal muscle relaxants [1.9.1, 1.9.3]. It is primarily prescribed for the short-term relief of acute, painful musculoskeletal conditions, such as those from sprains or muscle injuries [1.10.2, 1.10.4]. Carisoprodol works by acting on the central nervous system (CNS), specifically by interrupting pain sensations between the nerves and the brain, rather than acting on the muscles directly [1.9.1, 1.5.2]. Due to its potential for abuse and dependence, its use is typically limited to two to three weeks [1.9.1]. Carisoprodol itself is not an opioid. The Drug Enforcement Administration (DEA) classifies carisoprodol as a Schedule IV controlled substance, indicating a potential for abuse [1.7.1, 1.9.4]. Its effects are related to its main metabolite, meprobamate, which has sedative and anti-anxiety properties [1.5.2].

The Combination: Soma Compound with Codeine

While the standard Soma tablet does not contain codeine, there is a combination product called Soma Compound with Codeine [1.2.1, 1.2.4]. This formulation contains three active ingredients:

  • Carisoprodol (200 mg): The muscle relaxant.
  • Aspirin (325 mg): A nonsteroidal anti-inflammatory drug (NSAID) for pain and inflammation [1.2.4, 1.4.1].
  • Codeine Phosphate (16 mg): A narcotic analgesic (opioid) that acts on the central nervous system to relieve pain [1.2.4, 1.4.1].

This combination product is indicated when the additional pain-relieving action of an opioid is desired along with muscle relaxation [1.3.5]. Because it contains codeine, Soma Compound with Codeine is classified as a Schedule III controlled substance, facing stricter regulation than carisoprodol alone [1.6.1]. It is important to note that this specific combination product has been discontinued in the United States [1.4.5].

Carisoprodol vs. Codeine: A Comparison

The key difference between carisoprodol and codeine lies in their drug class and mechanism of action. Carisoprodol is a muscle relaxant, while codeine is an opioid pain reliever.

Feature Carisoprodol (Soma) Codeine
Drug Class Skeletal Muscle Relaxant [1.9.1] Opioid (Narcotic) Analgesic [1.4.1]
Mechanism Acts centrally in the brain and spinal cord to block pain sensation and relax muscles [1.5.2]. Binds to opioid receptors in the CNS to change the perception of pain [1.2.4].
Primary Use Short-term relief of acute, painful muscle spasms [1.10.4]. Relief of mild to moderate pain [1.2.4].
DEA Schedule Schedule IV [1.7.1] Schedule II (when alone), III or V in combinations [1.3.5, 1.6.1].
Common Side Effects Drowsiness, dizziness, headache [1.8.4]. Nausea, vomiting, constipation, sedation [1.2.4].

Risks of Combining Soma (Carisoprodol) and Opioids

Combining carisoprodol with any opioid, including codeine, significantly increases the risk of adverse effects. Both are central nervous system depressants, and their sedative effects are additive [1.3.4, 1.6.3]. This combination can lead to:

  • Profound sedation and drowsiness
  • Life-threatening respiratory depression (slowed or stopped breathing)
  • Dizziness and impaired motor coordination
  • Low blood pressure (hypotension)
  • Coma and death [1.6.2, 1.6.4]

Using carisoprodol with other CNS depressants like alcohol, benzodiazepines, or other opioids is strongly discouraged without strict medical supervision [1.3.3, 1.6.4]. Abusers sometimes combine Soma with opioids like Vicodin (hydrocodone) to produce a heroin-like effect, a practice that is extremely dangerous [1.7.3].

Conclusion: Clarifying the Ingredients

In conclusion, the standalone medication Soma contains only carisoprodol and does not have codeine. However, a specific, now-discontinued combination product, Soma Compound with Codeine, did include codeine along with aspirin [1.2.4, 1.4.5]. It is crucial for patients to know exactly which medication they have been prescribed. Given the serious risks of combining carisoprodol and opioids, patients should never mix these substances and should always inform their healthcare provider of all medications they are taking to avoid dangerous drug interactions [1.3.4].


For authoritative information on medication, consult a healthcare professional. One resource for drug information is the FDA's drug information portal.

Frequently Asked Questions

No, Soma (carisoprodol) is not an opioid or a narcotic. It is classified as a skeletal muscle relaxant [1.9.1]. However, it is a Schedule IV controlled substance due to its potential for abuse [1.7.1]. A separate, discontinued product called 'Soma Compound with Codeine' did contain the opioid codeine [1.4.5].

The active ingredient in Soma is carisoprodol [1.3.2]. It works on the central nervous system to relieve discomfort from acute muscle pain [1.5.2].

The most common side effects of Soma include drowsiness, dizziness, and headache [1.8.4]. It can impair mental and physical abilities, and for this reason, driving or operating heavy machinery should be avoided while taking it [1.8.1].

Soma (carisoprodol) is a Schedule IV controlled substance because it has a potential for abuse, dependence, and withdrawal [1.3.3, 1.7.1]. Its metabolite, meprobamate, has sedative properties that can be habit-forming [1.5.2].

No, you should not take Soma and codeine together unless specifically directed by a doctor. Both are central nervous system depressants, and combining them can cause additive effects like severe drowsiness, dangerously slowed breathing, coma, and even death [1.6.2, 1.6.4].

Soma is intended for short-term use, typically for periods of up to two or three weeks. There is no evidence of its effectiveness for long-term use, as most skeletal muscle injuries are of short duration [1.9.1, 1.10.2].

Abruptly stopping Soma after prolonged use can cause withdrawal symptoms. These may include insomnia, vomiting, abdominal cramps, headache, tremors, muscle twitching, anxiety, and in severe cases, hallucinations or psychosis [1.3.3, 1.8.2].

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.