The Discontinuation of Navane, but Not Thiothixene
For many years, thiothixene was a well-known antipsychotic prescribed under the brand name Navane. However, the manufacturer, Pfizer, discontinued the branded medication. For patients who have relied on this treatment, this news can cause concern. It is crucial to understand that while the brand name Navane is no longer on the market, the active ingredient, thiothixene, continues to be available in a generic capsule formulation. This is common practice in the pharmaceutical industry when a drug's patent expires, allowing other companies to produce a generic version at a lower cost.
It is important to note that not all formulations of the drug are still available. Search results show that the injectable preparation of thiothixene hydrochloride is no longer commercially available in the US. The concentrate formulation of thiothixene hydrochloride is also discontinued. This means patients must take the oral capsule form.
What is Thiothixene Used For?
Thiothixene is classified as a first-generation (or typical) antipsychotic agent. It is primarily used for the symptomatic management of schizophrenia in adults and children aged 12 and older. As a typical antipsychotic, its mechanism of action involves blocking dopamine D2 receptors in the brain. This action helps to reduce symptoms associated with psychosis, such as hallucinations, delusions, and disorganized thought. For some patients, it can be particularly effective in addressing withdrawn, apathetic, or unresponsive symptoms of chronic schizophrenia.
The Shift Towards Newer Antipsychotics
While thiothixene remains an effective option for many, its use has declined in recent decades in favor of newer, atypical antipsychotics. Medications like risperidone are often favored due to different side effect profiles and alternative mechanisms of action. The decision of which medication to use is a complex one, involving a careful evaluation of the patient's symptoms, overall health, potential side effects, and response to treatment. For example, some patients may respond better to a typical antipsychotic, while others may benefit more from the profile of an atypical one.
Availability of Generic Thiothixene
For those who continue to rely on this medication, the availability of generic thiothixene is a significant point. At least one manufacturer, Novitium Pharma, offers thiothixene capsules in various strengths. This ensures a consistent supply chain for patients who find this drug to be the most effective treatment for their condition. Patients can often find the generic version through a variety of pharmacies, both online and brick-and-mortar. Prescription services like Amazon Pharmacy, Blink Health, and HealthWarehouse list thiothixene capsules, often at competitive prices. It is important to remember that a valid prescription from a doctor is required for any purchase of this medication.
Where to obtain generic thiothixene
- Retail Pharmacies: Many major pharmacy chains stock generic thiothixene capsules. It is best to call your local pharmacy to confirm availability.
- Online Pharmacies: Reputable online pharmacies, such as Amazon Pharmacy and HealthWarehouse, offer the medication for delivery. Always ensure you are using a valid online pharmacy.
- Discount Cards and Programs: Services like GoodRx and Blink Health provide coupons that can reduce the cost of thiothixene, potentially making it more affordable.
Potential Side Effects and Considerations
Like all antipsychotics, thiothixene carries a risk of side effects. As a high-potency typical antipsychotic, it is more likely to cause extrapyramidal symptoms (EPS), such as tardive dyskinesia, akathisia, and muscle stiffness, than some newer agents.
- Common Side Effects: Drowsiness, dry mouth, blurred vision, restlessness, dizziness, and constipation are frequently reported.
- Serious Side Effects: These include tardive dyskinesia (potentially irreversible involuntary movements) and Neuroleptic Malignant Syndrome (NMS), a rare but life-threatening condition.
- Boxed Warning: The medication also carries a boxed warning regarding an increased risk of death in elderly patients with dementia-related psychosis. Therefore, it is not approved for this use.
Comparison Table: Thiothixene vs. a Common Atypical Antipsychotic
| Feature | Thiothixene | Risperidone |
|---|---|---|
| Class | First-Generation (Typical) Antipsychotic | Second-Generation (Atypical) Antipsychotic |
| Primary Use | Schizophrenia | Schizophrenia, Bipolar Disorder, Irritability associated with Autism |
| Availability | Generic Capsules | Generic and Brand Name (Risperdal) available |
| Common Side Effects | Drowsiness, EPS, dry mouth | Drowsiness, weight gain, dizziness, nausea |
| Serious Side Effects | Tardive Dyskinesia, NMS | Tardive Dyskinesia, NMS, Metabolic Changes |
| FDA Boxed Warning | Increased risk of death in elderly patients with dementia-related psychosis | Increased risk of death in elderly patients with dementia-related psychosis |
Conclusion
To answer the question, "is thiothixene available?," the answer is a definitive yes for the generic capsule form. While the brand-name product, Navane, and its injectable and concentrate forms are discontinued, generic thiothixene continues to be manufactured and prescribed for the treatment of schizophrenia. Patients taking this medication should not panic about its availability. However, it is essential for patients and caregivers to maintain an open dialogue with their healthcare providers regarding treatment options, especially given the range of newer atypical antipsychotics now available. The right medication for any individual depends on a careful assessment of their specific needs, risks, and health profile. For those who find thiothixene effective and tolerable, the generic capsule offers a reliable and accessible option for ongoing care. For more information, please consult the FDA's drug database: https://www.fda.gov/drugs.
