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Medications, Pharmacology: What is the difference between Voltaren and Aspercreme?

5 min read

As of 2024, Voltaren was the top-selling over-the-counter topical pain reliever. Understanding the fundamental distinction in their active ingredients is the key to knowing what is the difference between Voltaren and Aspercreme. Voltaren uses an NSAID to reduce inflammation, while Aspercreme products primarily use either a nerve-numbing anesthetic or a mild topical analgesic for minor aches.

Quick Summary

Voltaren and Aspercreme offer topical pain relief but use different active ingredients and mechanisms. Voltaren's diclofenac acts as an anti-inflammatory for arthritis, while Aspercreme uses lidocaine to numb nerves or trolamine salicylate as a topical analgesic for milder aches.

Key Points

  • Different Active Ingredients: Voltaren contains the NSAID diclofenac, while Aspercreme uses either the topical anesthetic lidocaine or the mild analgesic trolamine salicylate.

  • Distinct Mechanisms: Voltaren reduces pain by targeting inflammation, whereas Aspercreme with lidocaine numbs nerve endings to block pain signals.

  • Targeted vs. Broad Pain Relief: Voltaren is FDA-approved specifically for osteoarthritis joint pain, while Aspercreme is effective for a broader range of minor muscle aches, strains, and nerve-related pain.

  • Varying Speed of Relief: Aspercreme with lidocaine often provides faster, numbing relief, while Voltaren's anti-inflammatory effect may take up to a week for full efficacy.

  • Different Safety Considerations: Voltaren carries an NSAID boxed warning for cardiovascular and gastrointestinal risks, while Aspercreme has specific warnings related to aspirin-like compounds and local anesthetics.

  • Appropriate for Different Pain Types: Choose Voltaren for inflammatory arthritis pain and Aspercreme for nerve-based or milder muscle aches, depending on the specific formula.

In This Article

Core Difference in Active Ingredients and Mechanisms

At the heart of the difference between Voltaren and Aspercreme lies their active ingredients and how they work. Voltaren contains diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), while Aspercreme comes in several formulations, most commonly featuring either lidocaine (a topical anesthetic) or trolamine salicylate (a mild topical analgesic). This variation dictates not only the types of pain they are most effective against but also their specific uses and side effects.

How Voltaren Works

Voltaren Arthritis Pain Gel is formulated with 1% diclofenac sodium, a potent NSAID. Like its oral counterparts, topical diclofenac functions by inhibiting cyclooxygenase (COX) enzymes, which are responsible for producing prostaglandins—the chemicals that cause pain and inflammation in the body. By blocking these enzymes locally, Voltaren reduces swelling and tenderness directly at the application site. This anti-inflammatory action makes it particularly effective for chronic conditions driven by inflammation.

  • Recommended Use: Specifically, Voltaren is FDA-approved for relieving joint pain associated with osteoarthritis in areas such as the hands, wrists, elbows, feet, ankles, and knees.
  • Application: It is typically applied four times a day, and the full effect may take up to seven days to become noticeable.
  • Targeted Delivery: Its emulgel formula is designed to penetrate deeply through the skin to the joint and surrounding synovial tissue, delivering a sustained analgesic effect.

How Aspercreme Works (Multiple Formulations)

Aspercreme is a brand with a wider range of products, so understanding the specific formula is critical. The most popular versions are the Lidocaine formula and the Original formula.

  • Aspercreme with Lidocaine: This version contains 4% lidocaine, the maximum strength available over-the-counter. Lidocaine is a local anesthetic that works by blocking sodium channels in nerve membranes, preventing the nerves from sending pain signals to the brain. It is highly effective for numbing nerve-related pain and skin irritation, offering quick relief. It is often used for muscle aches, backaches, and joint pain not caused by arthritis.
  • Aspercreme Original: The classic formulation contains trolamine salicylate, a mild topical analgesic related to aspirin. Trolamine salicylate also inhibits the inflammatory response, though it is not as potent as Voltaren's diclofenac. This version is suitable for minor muscle pains, strains, sprains, and bruises.

Comparison Table: Voltaren vs. Aspercreme

Feature Voltaren (Diclofenac) Aspercreme (Lidocaine or Trolamine Salicylate)
Primary Active Ingredient Diclofenac Sodium 1% (NSAID) Lidocaine 4% or Trolamine Salicylate 10%
Mechanism of Action Inhibits COX enzymes to reduce inflammation and pain Lidocaine: Blocks nerve signals to numb pain.
Salicylate: Milder anti-inflammatory action.
Primary Uses Joint pain from osteoarthritis in specific joints (hands, wrists, elbows, knees, ankles, feet) Lidocaine: Minor aches, nerve pain, muscle soreness, backaches.
Salicylate: Minor muscle strains, sprains, backaches, bruises.
Speed of Relief May take up to 7 days for full effect, though some relief can be felt earlier Lidocaine: Fast-acting, numbing sensation often within minutes.
Salicylate: Can provide relief within an hour.
Who Should Avoid People with NSAID allergies, those with recent heart bypass surgery, pregnant women (late-stage) Lidocaine: Avoid if allergic to anesthetics. Not for wounds.
Salicylate: Avoid if allergic to aspirin or salicylates; not for children under 12.
Systemic Risks Boxed warning for increased risk of heart attack, stroke, and stomach bleeding (though lower than oral NSAIDs). Lower risk of systemic side effects, but possible with large-area application.
Application Area Restricted to specific joints, not for back, hips, or shoulders Suitable for a wider range of areas, including back, neck, and shoulders.

Choosing the Right Product for Your Pain

Selecting between Voltaren and Aspercreme depends largely on the nature and location of your pain. Here’s a breakdown to help guide your choice:

  • For Osteoarthritis Joint Pain: If you have diagnosed osteoarthritis causing joint pain in your hands, wrists, elbows, knees, ankles, or feet, Voltaren is the clinically proven and targeted choice due to its anti-inflammatory properties. Its ability to treat the underlying inflammation makes it more effective for chronic arthritis pain than a simple numbing agent. It is not recommended for other types of pain, such as muscle sprains or bruises.
  • For Muscle Aches and Minor Strains: For acute, minor pain from muscle strains, sprains, backaches, or bruises, Aspercreme is a versatile option. The lidocaine formula offers rapid numbing relief, targeting nerve pain quickly, while the salicylate version provides a milder, aspirin-like analgesic effect. The numbing action is often a preferred quick fix for surface-level pain.
  • For Nerve-Based Pain: The lidocaine-based Aspercreme is the superior choice for nerve-related pain and localized irritation, as its anesthetic properties are specifically designed to block nerve signals.

Important Safety Considerations

While both medications are applied topically, they carry different safety profiles that users must be aware of. Voltaren, as an NSAID, comes with serious warnings regarding cardiovascular and gastrointestinal risks, though the systemic absorption is minimal compared to oral versions. It is crucial to follow the application instructions precisely, as overuse or application to larger areas can increase absorption and risk.

Aspercreme products are generally well-tolerated, but precautions are necessary. The salicylate-based formula is not safe for children under 12 due to the risk of Reye’s syndrome and should be avoided by those with aspirin allergies. For both products, application to broken or irritated skin, tight bandaging, or use with external heat is strongly discouraged. Always consult a healthcare professional before combining topical pain relievers.

Conclusion: Making an Informed Decision

The choice between Voltaren and Aspercreme boils down to a specific diagnosis and the type of pain you're experiencing. Voltaren is the clear choice for treating the underlying inflammation of osteoarthritis in specific joints. In contrast, Aspercreme offers versatile, faster-acting relief for a broader range of minor muscle aches, strains, and nerve-based pain, especially with its lidocaine variant. By understanding the distinct mechanisms—anti-inflammatory for Voltaren versus nerve-numbing or mild analgesic for Aspercreme—consumers can select the most appropriate topical treatment for their needs, ensuring effective and targeted relief.

It is always wise to discuss your pain relief options with a doctor or pharmacist, especially if you have chronic pain or underlying health conditions. For detailed drug information, referring to authoritative sources like the U.S. National Library of Medicine’s DailyMed is highly recommended.

Frequently Asked Questions

No, using Voltaren and Aspercreme together is not recommended. Combining topical analgesics can increase the risk of side effects, and since they work differently, a doctor or pharmacist should advise on the appropriate treatment plan for your specific pain.

For inflammatory joint pain from osteoarthritis, Voltaren is generally considered more effective because its active ingredient, diclofenac, directly addresses the underlying inflammation. Aspercreme with lidocaine provides temporary numbness but does not treat the cause of inflammatory arthritis.

Aspercreme is recommended for backaches and muscle soreness. Voltaren, however, is typically only recommended for joint pain on the hands, wrists, elbows, feet, ankles, and knees and is not indicated for deep tissue areas like the back.

Aspercreme with lidocaine generally works faster, providing a numbing effect to block pain signals within minutes. The full effect of Voltaren, which addresses inflammation, can take up to seven days to become noticeable.

Common side effects for both can include skin irritation, redness, or itching at the application site. Voltaren carries stronger warnings related to NSAIDs, and Aspercreme (salicylate) should be avoided by those with aspirin allergies. Always read the label and consult a healthcare provider.

Aspercreme is typically better for minor muscle strains, especially the lidocaine version for immediate, targeted numbing relief or the salicylate version for a milder analgesic effect. Voltaren is specifically for arthritis pain, not muscle strains or sprains.

When used as directed, both are generally considered safe for most people, but they carry different risks. The risk of systemic side effects from Voltaren is minimal compared to oral NSAIDs but still carries a boxed warning. Aspercreme has a lower risk of systemic side effects but specific precautions, such as avoiding its use in those with aspirin sensitivity.

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.