The role of Werab 20 mg in treating acid-related disorders
Werab 20 mg is a brand name for a medication whose active ingredient is rabeprazole, a proton pump inhibitor (PPI). A doctor's prescription is required to obtain this medicine. Its primary purpose is to reduce the amount of acid produced in the stomach, providing relief from symptoms and allowing damaged gastrointestinal tissue to heal.
The mechanism of action
Rabeprazole, the active ingredient in Werab 20 mg, is an antisecretory compound that suppresses gastric acid secretion. It works by targeting the gastric proton pump (H+/K+-ATPase) in the stomach's parietal cells, irreversibly binding to and inactivating this enzyme system responsible for the final step of acid secretion. This process effectively reduces stomach acid concentration and increases the stomach's pH. The delayed-release tablets ensure the drug is absorbed in the small intestine before reaching the parietal cells.
What specific conditions are treated by Werab 20 mg?
Werab 20 mg is used to manage several acid-related conditions as determined by a healthcare provider.
- Gastroesophageal Reflux Disease (GERD): It treats GERD by controlling acid reflux and healing esophageal damage.
- Peptic Ulcer Disease: It promotes the healing of duodenal and gastric ulcers by reducing stomach acid.
- Helicobacter pylori (H. pylori) Eradication: It is part of combination therapy with antibiotics to eliminate H. pylori and heal ulcers.
- Zollinger-Ellison Syndrome: It manages this rare condition by controlling excessive stomach acid production.
Important considerations when taking Werab 20 mg
Discuss existing health issues with your doctor before taking Werab 20 mg, especially liver problems, bone disorders, or past allergic reactions. Consult your doctor if pregnant or breastfeeding.
Administration guidelines
Follow your doctor's instructions precisely.
- Swallow the tablet whole with water; do not chew or crush it.
- Werab is typically taken before a meal.
- For H. pylori eradication, it is often part of a specific regimen with antibiotics.
Potential side effects and long-term risks
Common side effects are generally mild, such as headache, nausea, and abdominal discomfort. Long-term use (over 3 months) can lead to:
- Low magnesium levels.
- Increased risk of bone fractures with use over one year.
- Vitamin B12 deficiency with use over three years.
- Increased risk of Clostridium difficile infection.
Drug interaction comparisons: Rabeprazole vs. Omeprazole
| Aspect | Werab 20 mg (Rabeprazole) | Omeprazole (e.g., Prilosec) |
|---|---|---|
| Metabolism Pathway | Less dependent on the CYP450 system | Extensively metabolized by CYP450 system |
| Pharmacogenetic Impact | Less affected by genetic variations in CYP2C19 | Affected by CYP2C19 genetic polymorphism |
| Drug-Drug Interaction Risk | Lower risk with CYP450-metabolized drugs | Higher potential for interactions |
| Onset of Action | Generally faster onset | Standard onset |
Conclusion
Werab 20 mg is an effective proton pump inhibitor for treating acid-related conditions like GERD, peptic ulcers, and Zollinger-Ellison syndrome. It reduces stomach acid, providing symptom relief and promoting healing. Be aware of potential side effects, especially with long-term use, and possible drug interactions. Always consult a healthcare professional for safe and appropriate use. More information on rabeprazole is available from the NHS.
