Tag: 11 hydroxy thc

THC is highly lipid-soluble, meaning it binds to fat molecules in your body, which can significantly prolong its effects and detection window [1.3.5, 1.3.4]. Understanding the pharmacology behind cannabis helps explain **why does being high last so long?**

While smoking's effects can begin within minutes, a high from edibles typically lasts 4 to 12 hours or more. The answer to 'Does smoking wear off faster than edibles?' is yes, due to fundamental differences in how the body processes cannabinoids, a concept central to pharmacology.

When you consume a cannabis edible, it is metabolized by the liver, which converts THC into a more potent compound called 11-hydroxy-THC [1.2.2]. This unique metabolic process is central to understanding how to flush edibles out of a system.