Tag: 16s rrna

Aminoglycoside-induced hearing loss has a widely varying incidence, with some studies reporting rates between 2% and 25% [1.8.4]. Understanding how these drugs work is key to their safe use. So, what is the binding site of gentamicin and how does it exert its powerful effects?

Aminoglycoside antibiotics exert their potent bactericidal effect by targeting the protein synthesis machinery of bacteria. A crucial question for understanding their mechanism is, where do aminoglycosides bind? The answer lies within the bacteria's 30S ribosomal subunit, a key component for translating genetic code into functional proteins.