Tag: 5 meo dmt

Research into psychedelics has seen a major resurgence, with the global drug user population rising 20% in the last decade to 292 million people [1.5.1]. This prompts the question: What's the strongest psychedelic drug available?

Surveys show that as of 2021, approximately 9% of people who have used recreational drugs have tried DMT [1.7.1]. But for those unfamiliar, **what does DMT compare to?** This powerful psychedelic is often mentioned alongside substances like psilocybin and LSD, but it possesses a unique profile.

Tryptamine derivatives are a class of compounds chemically related to the monoamine alkaloid tryptamine, and they often act as agonists at serotonin receptors. Among the most well-known is DMT, but this raises the question: what is the closest drug to DMT in terms of chemical structure and effect?

With potency estimated at 4 to 20 times that of regular DMT, 5-methoxy-N,N-dimethyltryptamine ($5-MeO-DMT$) is widely regarded as what is the most powerful DMT in terms of psychedelic intensity. This naturally occurring and synthetically produced tryptamine has a distinctive pharmacological profile and profound, though brief, effects on consciousness.

N,N-dimethyltryptamine (DMT) is a compound found in numerous plants and is also produced endogenously in the human body [1.3.2, 1.3.3]. So, what is the god molecule psychedelic and why has it earned this powerful name?