Tag: Abcb1

Over 480 drugs have been identified as P-glycoprotein (P-gp) substrates, with the number continually growing [1.8.5]. Understanding **what are examples of P-gp substrates** is crucial for predicting drug interactions and therapeutic outcomes, as P-gp can significantly alter a drug's absorption and distribution [1.5.6].

Overexpression of P-glycoprotein (P-gp) in cancer cells is a primary cause of multidrug resistance, a major hurdle in chemotherapy. Understanding **which drugs inhibit P-glycoprotein** is crucial for optimizing drug efficacy, overcoming resistance, and preventing adverse drug interactions.