Tag: Accelerated nodulosis

In up to 11.6% of methotrexate-treated rheumatoid arthritis patients, a phenomenon known as accelerated nodulosis can occur [1.4.1]. This raises a critical question for many: Does methotrexate cause cysts? The relationship is complex, often involving misidentification of other growths.

According to a review published in *Herald Scholarly Open Access*, methotrexate has been linked to the development of pulmonary rheumatoid nodules, a phenomenon known as accelerated nodulosis. This connection is particularly relevant for patients with conditions like rheumatoid arthritis, raising the question: **Can methotrexate cause lung nodules?**

While subcutaneous nodules are seen in about 25% of rheumatoid arthritis (RA) patients, a specific phenomenon known as accelerated nodulosis can be triggered by certain medications [1.2.1]. The central question for many is, what drug induced rheumatoid nodulosis most commonly? The primary culprit is methotrexate [1.2.2].

Though a cornerstone in treating rheumatoid arthritis (RA), methotrexate has a paradoxical side effect, known as methotrexate-induced accelerated nodulosis (MIAN), which can cause or accelerate the formation of rheumatoid nodules in susceptible individuals. This condition is notable because it can occur even when the medication is effectively controlling joint inflammation.