What is the most activating tricyclic antidepressant?
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4 min read
Initially developed in the 1950s, tricyclic antidepressants (TCAs) were some of the first medications used to treat depression, with protriptyline being a unique exception to the class's typical sedative properties. This secondary amine is widely considered the answer to **What is the most activating tricyclic antidepressant?**, offering an energizing effect rather than the typical drowsiness associated with many other TCAs.
