Tag: Activating antidepressants

According to clinical trial data, fatigue was reported in 12% of patients taking Zoloft, only slightly higher than the 8% in the placebo group. This highlights a key question in pharmacology: **is Zoloft more activating** or sedating compared to other antidepressants, and why do experiences vary so widely among users? The answer depends on individual brain chemistry, dosage, and how the medication interacts with the body.

Studies show that between 60-90% of patients with major depressive disorder (MDD) experience insomnia [1.3.4]. This raises a critical question for treatment: **which antidepressant is most likely to cause insomnia** or worsen pre-existing sleep problems?