Tag: Afterload

In patients with severe aortic stenosis, the heart’s ability to pump blood is already significantly compromised. This fixed obstruction to left ventricular outflow is the primary reason **why is hydralazine contraindicated in aortic stenosis** due to the severe hemodynamic consequences of its vasodilatory action.

Nitroglycerin was first used to treat angina pectoris in 1879, making nitrates one of the oldest therapies for this condition. In simple terms, how do nitrates treat angina? These powerful vasodilators primarily work by decreasing the heart's workload, which reduces its demand for oxygen and relieves chest pain.