Tag: Allosteric modulation

While a common perception exists that benzodiazepines increase GABA levels, this is a misconception; these drugs do not alter the brain's concentration of the neurotransmitter. Instead, they function as powerful modulators of GABA-A receptors, intensifying the brain's natural calming signals and amplifying GABA's inhibitory effects.

According to data on drug development, the field of allosteric modulation has seen a boom in recent years, making the term **PAM** crucial for modern pharmacology. In pharmacology, the acronym **PAM** refers both to the broad class of Positive Allosteric Modulators that enhance drug effects and the specific antidote Pralidoxime, each serving a distinct and vital purpose.