Yes, noncompetitive inhibitors can be irreversible: Exploring the covalent allosteric mechanism
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4 min read
According to technical documents from biochemical suppliers like Sigma-Aldrich, certain irreversible enzyme inhibitors are 'non-competitive in nature' because they permanently inactivate enzymes regardless of substrate concentration. The intricate answer to the question, 'Can noncompetitive inhibitors be irreversible?' lies in the nature of the chemical bond formed with the enzyme.
