Understanding the Science: What is the MOA of gabapentin?
•
4 min read
Although gabapentin was initially developed as a structural analog of the inhibitory neurotransmitter GABA, it does not act on GABA receptors. So, what is the MOA of gabapentin? The drug's primary mechanism involves binding to a specific auxiliary subunit of voltage-gated calcium channels (VGCCs) to regulate neuronal excitability and alleviate conditions like neuropathic pain and seizures.
