Tag: Aminoglycoside resistance

The emergence of antibiotic resistance is a critical global public health threat, leading to an estimated 1.27 million deaths directly attributable to drug-resistant pathogens in 2019. For the aminoglycoside class of antibiotics, a key factor undermining their effectiveness is bacterial resistance, with the most common mechanism of aminoglycoside resistance being their inactivation by enzymatic modification.

Most anaerobic bacteria are intrinsically resistant to aminoglycoside antimicrobial agents due to their lack of oxygen-dependent transport systems required for drug uptake. This poses significant challenges for treatment, highlighting the critical need to identify **what bacteria are resistant to aminoglycosides** before prescribing.