Can you take Linzess and Lubiprostone together?
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3 min read
While no direct drug-to-drug interactions have been explicitly reported between Linzess (linaclotide) and Lubiprostone (Amitiza), taking these two medications together is generally not recommended due to their similar mechanisms of action and a shared risk of severe diarrhea. Combining them could significantly increase the severity and likelihood of side effects.