Tag: Amitriptyline overdose

According to a clinical study on overdose, older tricyclic antidepressants like amitriptyline have a higher hospitalization and mortality rate in overdose cases compared to newer antidepressant classes. Given this, knowing what is a safe amount of amitriptyline to take is critical for anyone prescribed this medication, emphasizing the importance of strict adherence to medical guidance.

Tricyclic antidepressants like amitriptyline have a narrow therapeutic index, meaning the difference between a therapeutic dose and a toxic dose is relatively small, making an overdose a life-threatening event. A toxic amount of amitriptyline can disrupt the heart's electrical system, cause severe neurological symptoms, and lead to coma or death if not treated promptly.